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Amphiregulin (Human, Recombinant)

$395.00

Catalog Number: B2010292 (10 ug)
Amphiregulin (Human, Recombinant) is a high quality research product used as highly pure Amphiregulin (Human, Recombinant) expressed in HEK 293. This protein acts as an EGF receptor (EGFR) ligand that is important for the epithelial development in various organs. Custom bulk orders of this product are available upon request.

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SKU: B2010292 Categories: , ,

Description

Amphiregulin (Human, Recombinant)
Catalog number: B2010292
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Amphiregulin (Human, Recombinant) expressed in HEK 293. This protein acts as an EGF receptor (EGFR) ligand that is important for the epithelial development in various organs.
Storage: -20C
Keywords: rHuAmphiregulin; AR; AREG; Colorectum cell-derived growth factor; CRDGF
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Morimoto Y, Hirahara K, Kiuchi M, Wada T, Ichikawa T, Kanno T, Okano M,
Kokubo K, Onodera A, Sakurai D, Okamoto Y, Nakayama T. Amphiregulin-Producing
Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin
and Facilitate Airway Fibrosis. Immunity. 2018 Jul 17;49(1):134-150.e6.

2: Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N,
Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW,
Kopf M, Henderson NC, Zaiss DM. A Macrophage-Pericyte Axis Directs Tissue
Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Immunity. 2019 Mar 19;50(3):645-654.e6.

3: Wang H, Cai H, Wang X, Zhang M, Liu B, Chen Z, Yang T, Fang J, Zhang Y, Liu
W, Han J, Guo Q, Zhang H, Wang H, Xia G, Wang C. HDAC3 maintains oocyte meiosis
arrest by repressing amphiregulin expression before the LH surge. Nat Commun.
2019 Dec 16;10(1):5719.

4: Kefaloyianni E, Keerthi Raja MR, Schumacher J, Muthu ML, Krishnadoss V,
Waikar SS, Herrlich A. Proximal Tubule-Derived Amphiregulin Amplifies and
Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis. J Am Soc
Nephrol. 2019 Dec;30(12):2370-2383.

5: Dong L, Shi XH, Kang YK, Wei WB, Wang YX, Xu XL, Gao F, Yuan LH, Zhen J,
Jiang WJ, Jonas JB. Amphiregulin and ocular axial length. Acta Ophthalmol. 2019
May;97(3):e460-e470.

6: Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin
YE, Coppé JP, Lam EW, Campisi J, Sun Y. Targeting amphiregulin (AREG) derived
from senescent stromal cells diminishes cancer resistance and averts programmed
cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019
Dec;18(6):e13027.

7: Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle
T, Eltzschig HK. Hypoxia-inducible factor 2-alpha-dependent induction of
amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018
Feb 26;9(1):816.

8: Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi
M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM,
Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S. Osimertinib Overcomes
Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis
Model of ALK-Rearranged Lung Cancer. J Thorac Oncol. 2020 May;15(5):752-765.
9: Raimondo S, Saieva L, Vicario E, Pucci M, Toscani D, Manno M, Raccosta S,
Giuliani N, Alessandro R. Multiple myeloma-derived exosomes are enriched of
amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone
microenvironment leading to osteoclastogenesis. J Hematol Oncol. 2019 Jan
8;12(1):2.

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