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A new interesting article has been published in ANZ J Surg. 2019 Dec 11. doi: 10.1111/ans.15586. Review and titled:

Immunohistochemistry in screening for heritable colorectal cancer: what to do with an abnormal result.

Authors of this article are:

Paredes SR, Chan C, Rickard MJFX.

A summary of the article is shown below:

Recent developments in our understanding of molecular genetics have transformed screening and diagnostic practices for Lynch syndrome. The current standard involves universal tumour analysis of resected colorectal cancer (and ideally polypectomy) specimens using immunohistochemistry and molecular techniques. Patients with abnormal immunohistochemical findings are subsequently referred for definitive mutational testing. This review relates the molecular pathogenesis of Lynch syndrome to current immunohistochemistry-based screening strategies and discusses the interpretation and clinical implications of screening results.© 2019 Royal Australasian College of Surgeons.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31828933 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Lynch syndrome; cancer screening; colorectal cancer; colorectal surgery; hereditary cancer; immunohistochemistry.

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