Uracil (Highly Pure)

Description

Uracil (Highly Pure)
Catalog number: B2014332
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 112.09 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: 2,4(1H,3H)-Pyrimidinedione, 2,4-Dihydroxypyrimidine, 2,4-Pyrimidinediol
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hagen L, Pea-Diaz J, Kavli B, Otterlei M, Slupphaug G, Krokan HE. Genomic uracil and human disease Exp Cell Res. 2006 Aug 15;312(14):2666-72.
2: Sire J, Qurat G, Esnault C, Priet S. Uracil within DNA: an actor of antiviral immunity Retrovirology. 2008 Jun 5;5:45.
3: Kavli B, Otterlei M, Slupphaug G, Krokan HE. Uracil in DNA–general mutagen, but normal intermediate in acquired immunity DNA Repair (Amst). 2007 Apr 1;6(4):505-16.
4: Paasz A, Cie_ D. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications Eur J Med Chem. 2015 Jun 5;97:582-611.
5: Meshcheryakova S, Shumadalova A, Beylerli O, Gareev I, Zhao S, Wu J. Innovative antimicrobial substances based on uracil S-derivatives Drug Dev Res. 2022 May;83(3):578-585.
6: CULLUMBINE H, SIMPSON M. Thiothymine (2-thio-5-methyl-uracil) Nature. 1947 May 17;159(4046):680.
7: van den Wildenberg SAH, Streng AS, van den Broek R, Broeren MAC, Deenen MJ, van Dongen JLJ, Hanrath MA, Lapr C, Brunsveld L, Scharnhorst V, van de Kerkhof D. Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions J Pharm Biomed Anal. 2022 Nov 30;221:115027.
8: Meshesha M, Esadze A, Cui J, Churgulia N, Sahu SK, Stivers JT. Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages PLoS One. 2020 Jul 14;15(7):e0235012.
9: Paramonova MP, Gureeva ES, Ozerov AA, Snoeck R, Andrei G, Alexandrov DA, Handazinskaya AL, Novikov MS, Kochetkov SN. Synthesis of 1-[-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication Dokl Biochem Biophys. 2022 Dec;507(1):357-362.
10: Colasurdo DD, Pila MN, Iglesias DA, Laurella SL, Ruiz DL. Tautomerism of uracil and related compounds: A mass spectrometry study Eur J Mass Spectrom (Chichester). 2018 Apr;24(2):214-224.

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