Tyrphostin A1 (Highly Pure)


Catalog Number: B2012407 (50 mg)
Tyrphostin A1 (Highly Pure) is a high quality Tyrphostin A1. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Tyrphostin A1 (Highly Pure)
Catalog number: B2012407
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 184.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Tyrphostin 1, (4-Methoxybenzylidene)malononitrile
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Du C, Bright JJ, Sriram S. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice J Neuroimmunol. 2001 Mar 1;114(1-2):69-79.
2: Bright JJ, Du C, Sriram S. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis J Immunol. 1999 May 15;162(10):6255-62.
3: Dickenson JM, Hill SJ. Potentiation of adenosine A1 receptor-mediated inositol phospholipid hydrolysis by tyrosine kinase inhibitors in CHO cells Br J Pharmacol. 1998 Nov;125(5):1049-57.
4: Ogura T, Imanishi S, Shibamoto T. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes Jpn J Pharmacol. 2001 Nov;87(3):235-9.
5: Andreis PG, Neri G, Tortorella C, Gottardo L, Nussdorfer GG. Tyrphostin-23 enhances steroid-hormone secretion from dispersed human and rat adrenocrotical cells Endocr Res. 2000 Aug;26(3):319-32.
6: Ramdas L, Obeyesekere NU, McMurray JS, Gallick GE, Seifert WE Jr, Budde RJ. A tyrphostin-derived inhibitor of protein tyrosine kinases: isolation and characterization Arch Biochem Biophys. 1995 Nov 10;323(2):237-42.
7: Faaland CA, Mermelstein FH, Hayashi J, Laskin JD. Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity Mol Cell Biol. 1991 May;11(5):2697-703.
8: Blumrich EM, Kadam R, Dringen R. The Protein Tyrosine Kinase Inhibitor Tyrphostin 23 Strongly Accelerates Glycolytic Lactate Production in Cultured Primary Astrocytes Neurochem Res. 2016 Oct;41(10):2607-2618.
9: Tan CM, Xenoyannis S, Feldman RD. Oxidant stress enhances adenylyl cyclase activation Circ Res. 1995 Oct;77(4):710-7.
10: Missan S, Qi J, Crack J, McDonald TF, Linsdell P. Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase Pflugers Arch. 2009 Jul;458(3):471-80.

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