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Tumor Necrosis Factor-alpha/TNFSF2 (Human)

$495.00

Catalog Number: B2010326 (10 ug)
Tumor Necrosis Factor-alpha/TNFSF2 (Human) is a high quality research product used as highly pure Tumor Necrosis Factor-alpha/TNFSF2 (Human) expressed in P. pastoris. This protein acts as a strong pro-inflammatory cytokine with tumor cell targeting capability and with low toxicity levels towards healthy cells. Custom bulk orders of this product are available upon request.

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SKU: B2010326 Categories: ,

Description

Tumor Necrosis Factor-alpha/TNFSF2 (Human)
Catalog number: B2010326
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Tumor Necrosis Factor-alpha/TNFSF2 (Human) expressed in P. pastoris. This protein acts as a strong pro-inflammatory cytokine with tumor cell targeting capability and with low toxicity levels towards healthy cells.
Storage: -20C
Keywords: rHuTNF-α/TNFSF2; TNF-alpha; Cachectin; DIF; TNFA; Differentiation-inducing factor
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Juuti-Uusitalo K, Klunder LJ, Sjollema KA, Mackovicova K, Ohgaki R, Hoekstra
D, Dekker J, van Ijzendoorn SC. Differential effects of TNF (TNFSF2) and IFN-γ
on intestinal epithelial cell morphogenesis and barrier function in three-
dimensional culture. PLoS One. 2011;6(8):e22967.

2: Chen H, Zhang X, Liao N, Ji Y, Mi L, Gan Y, Su Y, Wen F. Identification of
NLRP3 Inflammation-Related Gene Promoter Hypomethylation in Diabetic
Retinopathy. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):12.

3: Heimroth RD, Casadei E, Salinas I. Molecular Drivers of Lymphocyte
Organization in Vertebrate Mucosal Surfaces: Revisiting the TNF Superfamily
Hypothesis. J Immunol. 2020 May 15;204(10):2697-2711.

4: Kirkpatrick A, Bidwell J, van den Brule AJ, Meijer CJ, Pawade J, Glew S.
TNFalpha polymorphism frequencies in HPV-associated cervical dysplasia. Gynecol
Oncol. 2004 Feb;92(2):675-9.

5: Mitsuhashi M, Targan SR. Ex vivo simulation of IgG Fc and T-cell receptor
functions: an application to inflammatory bowel disease. Inflamm Bowel Dis. 2008
Aug;14(8):1061-7.

6: Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C,
Lerner UH. Inhibition of lipopolysaccharide-induced osteoclast formation and
bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc
Biol. 2017 May;101(5):1233-1243.

7: Kato Y, Mitsuhashi M. [Prediction of WT1/MUC1 peptide dendritic cell therapy
responders by quantification of ex vivo induced mRNA in whole blood]. Gan To
Kagaku Ryoho. 2012 Nov;39(12):1803-5.

8: Wei SC, Ni YH, Yang HI, Su YN, Chang MC, Chang YT, Shieh MJ, Wang CY, Wong
JM. A hospital-based study of clinical and genetic features of Crohn’s disease.
J Formos Med Assoc. 2011 Sep;110(9):600-6.
9: Tovar V, Ogura M, Kobayashi A, Kimura S, Saito K, Kainuma M, Yohda M,
Hasegawa S, Mitsuhashi M. A dried tofu-supplemented diet affects mRNA expression
of inflammatory cytokines in human blood. J Nutr Sci Vitaminol (Tokyo).
2010;56(6):396-410.

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