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Tacrolimus Streptavidin Conjugate [(PEG)11 Linker]

$1,450.00 $995.00

Catalog #: P2010029 (1 mg)

Highly pure and concentrated solution of Tacrolimus conjugated to Streptavidin via a very stable (PEG)11-Biotin linkage. The extra long linker offers flexibility and solubility to the Tacrolimus moiety. Unlike free Tacrolimus and its smaller conjugates, Tacrolimus-(PEG)11-Biotin Streptavidin is readily soluble in aqueous buffers. Each Streptavidin molecule contains several Tracrolimus units. Dilutions of the provided conjugate can be made in 1X Phosphate Buffer Saline, pH 7.4. This conjugate is ideal for Tacrolimus immobilization on solid surfaces, adsorption on membranes and use for a wide variety of Tacrolimus detection applications.

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Description

Tacrolimus Streptavidin Conjugate Solution [(PEG)11 Linker]

Catalog # P2010029
Size 1.00 mg
Other Names Streptavidin-Tacrolimus, Tacrolimus-Streptavidin, Streptavidin conjugated to Tacrolimus, FK506-Streptavidin, Streptavidin-FK506, Tacrolimus_Streptavidin Conjugate, Tacrolimus [Streptavidin].
Molecular Weight 54.4 kDa (average)
Concentration 1.0 mg/mL
Purity >95%
Storage -20°C. Avoid repeated freeze/thaw cycles.
Supplied as Liquid solution
Buffer 1X Phosphate Buffer Saline, pH 7.4.
Keywords Streptavidin conjugate, Tacrolimus 32, Tacrolimus, FK-506, Fujimycin, Prograf, Advagraf, Protopic

References

  • Brunet, M., Plana, J. C., and Rimola, A. (2001). Tacrolimus. Madrid: Drug Farma.
  • Goto, T., and Nakagawa, H. (2004). Development of Tacrolimus Ointment. Tacrolimus Ointment, 81–98.
  • Raptis, D., and Pramateftakis, M.-G. (2013). Tacrolimus: Effectiveness, safety and drug interactions. New York: Nova Biomedical.
  • Plosker, G. L., and Foster, R. H. (2001). Tacrolimus a further update of its pharmacology and therapeutic use in the management of organ transplantation. Auckland: ADIS International.
  • Kaplan, B., Burckart, G. J., and Lakkis, F. G. (2012). Immunotherapy in transplantation: principles and practice. Chichester, West Sussex, UK: Wiley Blackwell.
  • Oberbauer R, Bestard O, Furian L, Maggiore U, Pascual J, Rostaing L, Budde K. Optimization of tacrolimus in kidney transplantation: New pharmacokinetic perspectives. Transplant Rev (Orlando). 2020 Jan 13:100531.
  • Sanches-Silva A, Testai L, Nabavi SF, Battino M, Pandima Devi K, Tejada S, Sureda A, Xu S, Yousefi B, Majidinia M, Russo GL, Efferth T, Nabavi SM, Farzaei MH. Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway. Pharmacol Res. 2020 Feb;152:104626.
  • Akbari M, Soltani Moghadam R, Elmi R, Nosrati A, Taghiabadi E, Aghdami N. Topical Tacrolimus as an adjunct to Conventional Therapy for Stromal Herpetic Keratitis: a Randomized Clinical Trial. J Ophthalmic Vis Res. 2019 Oct 24;14(4):400-411.
  • Plasmeijer EI, Sachse MM, Gebhardt C, Geusau A, Bouwes Bavinck JN. Cutaneous squamous cell carcinoma (cSCC) and immunosurveillance – the impact of immunosuppression on frequency of cSCC. J Eur Acad Dermatol Venereol. 2019 Dec;33 Suppl 8:33-37.

Tacrolimus Conjugates Flyer

Tacrolimus Conjugates Flyer

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