Succinyl-CoA Synthetase (Highly Pure)

Product Description

Succinyl-CoA Synthetase (Highly Pure)
Catalog number: B2012603
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 29.8 kDa (α), 41.4 kDa (β)
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: SCS, Succinate Thiokinase, Succinyl Coenzyme A Synthetase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Huang J, Fraser ME. Tartryl-CoA inhibits succinyl-CoA synthetase Acta Crystallogr F Struct Biol Commun. 2020 Jul 1;76(Pt 7):302-308.
2: Wu B, Qiu J, Zhao TV, Wang Y, Maeda T, Goronzy IN, Akiyama M, Ohtsuki S, Jin K, Tian L, Goronzy JJ, Weyand CM. Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells Cell Metab. 2020 Dec 1;32(6):967-980.e5.
3: Huang J, Fraser ME. The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase Acta Crystallogr F Struct Biol Commun. 2022 Oct 1;78(Pt 10):363-370.
4: Nishimura JS. Succinyl-CoA synthetase structure-function relationships and other considerations Adv Enzymol Relat Areas Mol Biol. 1986;58:141-72.
5: Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells Mol Cell. 2021 Jun 3;81(11):2303-2316.e8.
6: Huang J, Nguyen VH, Hamblin KA, Maytum R, van der Giezen M, Fraser ME. ATP-specificity of succinyl-CoA synthetase from Blastocystis hominis Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):647-659.
7: Huang J, Fraser ME. Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase Acta Crystallogr D Struct Biol. 2021 Mar 1;77(Pt 3):357-368.
8: Liu X, Si W, He L, Yang J, Peng Y, Ren J, Liu X, Jin T, Yu H, Zhang Z, Cheng X, Zhang W, Xia L, Huang Y, Wang Y, Liu S, Shan L, Zhang Y, Yang X, Li H, Liang J, Sun L, Shang Y. The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry Signal Transduct Target Ther. 2021 Nov 3;6(1):375.
9: Gomes C, Palma N, Pons MJ, Magallón-Tejada A, Sandoval I, Tinco-Valdez C, Gutarra C, Del Valle-Mendoza J, Ruiz J, Matsuoka M. Succinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis PLoS Negl Trop Dis. 2016 Sep 14;10(9):e0004989.
10: Vashisht K, Singh P, Verma S, Dixit R, Mishra N, Pandey KC. The nucleotide specificity of succinyl-CoA synthetase of Plasmodium falciparum is not determined by charged gatekeeper residues alone FEBS Open Bio. 2021 Mar;11(3):578-587.

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