Staurosporine Kinase Inhibitor

Description

Staurosporine Kinase Inhibitor
Catalog number: B2012719
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 200 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: PKC inhibitor, protein kinase C inhibitor
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Stevanovic M, D’Agostino PM, Mojicevic M, Gulder TAM, Nikodinovic-Runic J, Vojnovic S. Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production J Appl Microbiol. 2022 Oct;133(4):2560-2568.
2: Zhou B, Hu ZJ, Zhang HJ, Li JQ, Ding WJ, Ma ZJ. Bioactive staurosporine derivatives from the Streptomyces sp. NB-A13 Bioorg Chem. 2019 Feb;82:33-40.
3: Khosravi Babadi Z, Ebrahimipour G, Wink J, Narmani A, Risdian C. Isolation and identification of Streptomyces sp. Act4Zk, a good producer of Staurosporine and some derivatives Lett Appl Microbiol. 2021 Feb;72(2):206-218.
4: Mojicevic M, D’Agostino PM, Pavic A, Vojnovic S, Senthamaraikannan R, Vasiljevic B, Gulder TAM, Nikodinovic-Runic J. Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties Microbiologyopen. 2020 Mar;9(3):e986.
5: Cartuche L, Sifaoui I, Cruz D, Reyes-Batlle M, López-Arencibia A, Javier Fernández J, Díaz-Marrero AR, Piñero JE, Lorenzo-Morales J. Staurosporine from Streptomyces sanyensis activates Programmed Cell Death in Acanthamoeba via the mitochondrial pathway and presents low in vitro cytotoxicity levels in a macrophage cell line Sci Rep. 2019 Aug 12;9(1):11651.
6: Kim BY, Zucchi TD, Fiedler HP, Goodfellow M. Streptomyces staurosporininus sp. nov., a staurosporine-producing actinomycete Int J Syst Evol Microbiol. 2012 Apr;62(Pt 4):966-970.
7: Cui T, Lin S, Wang Z, Fu P, Wang C, Zhu W. Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380 Front Microbiol. 2022 Jul 12;13:957473.
8: Cheng J, Park SB, Kim SH, Yang SH, Suh JW, Lee CH, Kim JG. Suppressing activity of staurosporine from Streptomyces sp. MJM4426 against rice bacterial blight disease J Appl Microbiol. 2016 Apr;120(4):975-85.
9: Park BS, Abdel-Azeem AZ, Al-Sanea MM, Yoo KH, Tae JS, Lee SH. Staurosporine analogues from microbial and synthetic sources and their biological activities Curr Med Chem. 2013;20(31):3872-902.
10: Guan H, Li Y, Zheng J, Liu N, Zhang J, Tan H. Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576 Sci China Life Sci. 2019 Dec;62(12):1638-1654.

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