STAT5B Protein

Description

STAT5B Protein
Catalog number: B2014588
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 μg
Molecular Weight or Concentration: 115 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: STAT5B Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Pelham SJ, Caldirola MS, Avery DT, Mackie J, Rao G, Gothe F, Peters TJ, Guerin A, Neumann D, Vokurkova D, Hwa V, Zhang W, Lyu SC, Chang I, Manohar M, Nadeau KC, Gaillard MI, Bezrodnik L, Iotova V, Zwirner NW, Gutierrez M, Al-Herz W, Goodnow CC, Vargas-Hernández A, Forbes Satter LR, Hambleton S, Deenick EK, Ma CS, Tangye SG. STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis J Allergy Clin Immunol. 2022 Oct;150(4):931-946.
2: Rani A, Murphy JJ. STAT5 in Cancer and Immunity J Interferon Cytokine Res. 2016 Apr;36(4):226-37.
3: Subramaniam D, Angulo P, Ponnurangam S, Dandawate P, Ramamoorthy P, Srinivasan P, Iwakuma T, Weir SJ, Chastain K, Anant S. Suppressing STAT5 signaling affects osteosarcoma growth and stemness Cell Death Dis. 2020 Feb 24;11(2):149.
4: Monaghan KL, Aesoph D, Ammer AG, Zheng W, Rahimpour S, Farris BY, Spinner CA, Li P, Lin JX, Yu ZX, Lazarevic V, Hu G, Leonard WJ, Wan ECK. Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2116256118.
5: Veloso A, Cools J. Targeting STAT5B in T-cell acute lymphoblastic leukemia Blood. 2023 Jul 20;142(3):215-217.
6: Kaneshige A, Bai L, Wang M, McEachern D, Meagher JL, Xu R, Wang Y, Jiang W, Metwally H, Kirchhoff PD, Zhao L, Jiang H, Wang M, Wen B, Sun D, Stuckey JA, Wang S. A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo Nat Chem Biol. 2023 Jun;19(6):703-711.
7: de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT. Structural and functional consequences of the STAT5B(N642H) driver mutation Nat Commun. 2019 Jun 7;10(1):2517.
8: Barilà G, Calabretto G, Teramo A, Vicenzetto C, Gasparini VR, Semenzato G, Zambello R. T cell large granular lymphocyte leukemia and chronic NK lymphocytosis Best Pract Res Clin Haematol. 2019 Sep;32(3):207-216.
9: Smith MR, Satter LRF, Vargas-Hernández A. STAT5b: A master regulator of key biological pathways Front Immunol. 2023 Jan 23;13:1025373.
10: Dempsey LA. STAT5 facts Nat Immunol. 2023 Jan;24(1):1.

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