SPAM1 Human Protein

Description

SPAM1 Human Protein
Catalog number: B2014116
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 μg
Molecular Weight or Concentration: 52.1 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: HYA1, HYAL1, HYAL3, HYAL5, PH-20, SPAG15
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: G_mez-Torres MJ, Sez-Espinosa P, Manzano-Santiago P, Robles-G_mez L, Huerta-Retamal N, Aizpurua J. Sperm Adhesion Molecule 1 (SPAM1) Distribution in Selected Human Sperm by Hyaluronic Acid Test Biomedicines. 2022 Oct 13;10(10):2553.
2: Dunn CA, Mager DL. Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus BMC Genomics. 2005 Apr 1;6:47.
3: Martin-DeLeon PA. Epididymal SPAM1 and its impact on sperm function Mol Cell Endocrinol. 2006 May 16;250(1-2):114-21.
4: Chen H, Griffiths G, Galileo DS, Martin-DeLeon PA. Epididymal SPAM1 is a marker for sperm maturation in the mouse Biol Reprod. 2006 May;74(5):923-30.
5: Park S, Kim YH, Jeong PS, Park C, Lee JW, Kim JS, Wee G, Song BS, Park BJ, Kim SH, Sim BW, Kim SU, Triggs-Raine B, Baba T, Lee SR, Kim E. SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defect FASEB J. 2019 Dec;33(12):14440-14449.
6: Griffiths GS, Galileo DS, Aravindan RG, Martin-DeLeon PA. Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes Biol Reprod. 2009 Sep;81(3):562-70.
7: Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H, Galileo DS. Spam1-associated transmission ratio distortion in mice: elucidating the mechanism Reprod Biol Endocrinol. 2005 Aug 10;3:32.
8: Reese KL, Aravindan RG, Griffiths GS, Shao M, Wang Y, Galileo DS, Atmuri V, Triggs-Raine BL, Martin-Deleon PA. Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm Mol Reprod Dev. 2010 Sep;77(9):759-72.
9: Evans EA, Zhang H, Martin-DeLeon PA. SPAM1 (PH-20) protein and mRNA expression in the epididymides of humans and macaques: utilizing laser microdissection/RT-PCR Reprod Biol Endocrinol. 2003 Aug 6;1:54.
10: Morales CR, Badran H, El-Alfy M, Men H, Zhang H, Martin-DeLeon PA. Cytoplasmic localization during testicular biogenesis of the murine mRNA for Spam1 (PH-20), a protein involved in acrosomal exocytosis Mol Reprod Dev. 2004 Dec;69(4):475-82.

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