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SARS-CoV-2 Spike RBD Alpha Variant

$895.00

Catalog Number: B2010498 (100 ug)
SARS-CoV-2 Spike RBD Alpha Variant is a highly pure recombinant SARS-CoV-2 RBD from the Alpha Variant lineage (B.1.1.7, with N501Y mutation) expressed in HEK293 cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2010498 Categories: ,

Description

SARS-CoV-2 Spike RBD Alpha Variant
Catalog number: B2010498
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 27 kDa
Supplied as: Lyophilized Powder
Applications: molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants
Storage: -20℃
Keywords: Alpha Variant Spike, B.1.1.7 Spike RBD, Alpha RBD
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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A, Le Guen J, Kassis-Chikhani N, Edriss D, Belec L, Seve A, Courtellemont L,
Péré H, Hocqueloux L, Fafi-Kremer S, Prazuck T, Mouquet H, Bruel T, Simon-
Lorière E, Rey FA, Schwartz O. Reduced sensitivity of SARS-CoV-2 variant Delta
to antibody neutralization. Nature. 2021 Aug;596(7871):276-280.

2: Zahradník J, Marciano S, Shemesh M, Zoler E, Harari D, Chiaravalli J, Meyer
B, Rudich Y, Li C, Marton I, Dym O, Elad N, Lewis MG, Andersen H, Gagne M, Seder
RA, Douek DC, Schreiber G. SARS-CoV-2 variant prediction and antiviral drug
design are enabled by RBD in vitro evolution. Nat Microbiol. 2021
Sep;6(9):1188-1198

3: Kim Y, Gaudreault NN, Meekins DA, Perera KD, Bold D, Trujillo JD, Morozov I,
McDowell CD, Chang KO, Richt JA. Effects of Spike Mutations in SARS-CoV-2
Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and
Neutralization. bioRxiv [Preprint]. 2021 Aug 25:2021.08.25.457627.

4: Jawad B, Adhikari P, Podgornik R, Ching WY. Key Interacting Residues between
RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics
Simulation and Density Functional Calculation. J Chem Inf Model. 2021 Aug
24:acs.jcim.1c00560.

5: Kim S, Liu Y, Lei Z, Dicker J, Cao Y, Zhang XF, Im W. Differential
Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.
bioRxiv [Preprint]. 2021 Jul 26:2021.07.23.453598.

6: Rattanapisit K, Bulaon CJI, Khorattanakulchai N, Shanmugaraj B, Wangkanont K,
Phoolcharoen W. Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants
showed differential binding efficiency with anti-spike specific monoclonal
antibodies. PLoS One. 2021 Aug 11;16(8):e0253574.

7: Lu L, Chu AW, Zhang RR, Chan WM, Ip JD, Tsoi HW, Chen LL, Cai JP, Lung DC,
Tam AR, Yau YS, Kwan MY, To WK, Tsang OT, Lee LL, Yi H, Ip TC, Poon RW, Siu GK,
Mok BW, Cheng VC, Chan KH, Yuen KY, Hung IF, To KK. The impact of spike N501Y
mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent
serum. EBioMedicine. 2021 Aug 19;71:103544.

8: Barton MI, MacGowan SA, Kutuzov MA, Dushek O, Barton GJ, van der Merwe PA.
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human
ACE2 receptor on binding affinity and kinetics. Elife. 2021 Aug 26;10:e70658.

9: Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P. N501Y
mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor
ACE2. Elife. 2021 Aug 20;10:e69091.
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NG, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H,
Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi
A. Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for
host ACE2. J Biol Chem. 2021 Aug 31:101151.

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