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Recombinant Human TSHR Fc Chimeric Protein

$595.00 $295.00

Catalog Number: B2010251 (50 ug)
Recombinant Human TSHR Fc Chimera Protein is a high quality research product used as high purity TSH receptor conjugated to the Fc region of IgG. This product has been validated in many immuno-applications using Human TSH alpha/beta as antigen. Custom bulk orders of this product are available upon request.

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SKU: B2010251 Categories: , ,

Description

Recombinant Human TSHR Fc Chimeric Protein
Catalog number: B2010251
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 50 ug
pH: na
Supplied as: Reconstitute before use
Appearance: Lyophilized
Applications: high purity TSH receptor conjugated to the Fc region of IgG. This product has been validated in many immuno-applications using Human TSH alpha/beta as antigen.
Storage: -20C
Keywords: Thyroid Stimulating Hormone Receptor
Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um.

References:
1: Pujol-Borrell R, Álvarez-Sierra D, Jaraquemada D, Marín-Sánchez A, Colobran
R. Central Tolerance Mechanisms to TSHR in Graves’ Disease: Contributions to
Understand the Genetic Association. Horm Metab Res. 2018 Dec;50(12):863-870.

2: Zhou L, Wu K, Zhang L, Gao L, Chen S. Liver-specific deletion of TSHR
inhibits hepatic lipid accumulation in mice. Biochem Biophys Res Commun. 2018
Feb 26;497(1):39-45.

3: Liu T, Men Q, Su X, Chen W, Zou L, Li Q, Song M, Ouyang D, Chen Y, Li Z, Fu
X, Yang A. Downregulated expression of TSHR is associated with distant
metastasis in thyroid cancer. Oncol Lett. 2017 Dec;14(6):7506-7512.

4: Pujol-Borrell R, Giménez-Barcons M, Marín-Sánchez A, Colobran R. Genetics of
Graves’ Disease: Special Focus on the Role of TSHR Gene. Horm Metab Res. 2015
Sep;47(10):753-66.

5: Huth S, Jaeschke H, Schaarschmidt J, Paschke R. Controversial constitutive
TSHR activity: patients, physiology, and in vitro characterization. Horm Metab
Res. 2014 Jun;46(7):453-61.

6: Fang Y, Sun F, Zhang RJ, Zhang CR, Yan CY, Zhou Z, Zhang QY, Li L, Ying YX,
Zhao SX, Liang J, Song HD. Mutation screening of the TSHR gene in 220 Chinese
patients with congenital hypothyroidism. Clin Chim Acta. 2019 Oct;497:147-152.

7: Sugisawa C, Abe K, Sunaga Y, Taniyama M, Hasegawa T, Narumi S. Identification
of compound heterozygous TSHR mutations (R109Q and R450H) in a patient
with nonclassic TSH resistance and functional characterization of the mutant
receptors. Clin Pediatr Endocrinol. 2018;27(3):123-130.

8: Zhou C, Li J, Wang Y, Xue S, Zhang Y. Association of BRAF gene and TSHR with
cervical lymph node metastasis of papillary thyroid microcarcinoma. Oncol Lett.
2019 Jan;17(1):183-194.

9: Furmaniak J, Sanders J, Núñez Miguel R, Rees Smith B. Mechanisms of Action of
TSHR Autoantibodies. Horm Metab Res. 2015 Sep;47(10):735-52.

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