Recombinant Human Thymine-DNA Glycosylase Protein

Product Description

Recombinant Human Thymine-DNA Glycosylase Protein
Catalog number: B2012793
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Thymine-DNA Glycosylase, human, recombinant
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hardeland U, Bentele M, Lettieri T, Steinacher R, Jiricny J, Schär P. Thymine DNA glycosylase Prog Nucleic Acid Res Mol Biol. 2001;68:235-53.
2: He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA Science. 2011 Sep 2;333(6047):1303-7.
3: Yoon JH, Iwai S, O’Connor TR, Pfeifer GP. Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair Nucleic Acids Res. 2003 Sep 15;31(18):5399-404.
4: Sibghat-Ullah, Gallinari P, Xu YZ, Goodman MF, Bloom LB, Jiricny J, Day RS 3rd. Base analog and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA-glycosylase Biochemistry. 1996 Oct 1;35(39):12926-32.
5: Zhu B, Zheng Y, Angliker H, Schwarz S, Thiry S, Siegmann M, Jost JP. 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence Nucleic Acids Res. 2000 Nov 1;28(21):4157-65.
6: Hang B, Medina M, Fraenkel-Conrat H, Singer B. A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13561-6.
7: Hardeland U, Bentele M, Jiricny J, Schär P. The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs Nucleic Acids Res. 2003 May 1;31(9):2261-71.
8: Neddermann P, Gallinari P, Lettieri T, Schmid D, Truong O, Hsuan JJ, Wiebauer K, Jiricny J. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase J Biol Chem. 1996 May 31;271(22):12767-74.
9: Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Stoerker J, Genuardi M, Yeung AT, Matsumoto Y, Bellacosa A. Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase J Biol Chem. 2000 Oct 20;275(42):32422-9.
10: Coey CT, Malik SS, Pidugu LS, Varney KM, Pozharski E, Drohat AC. Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues Nucleic Acids Res. 2016 Dec 1;44(21):10248-10258.

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