Recombinant Human Midkine Protein

Description

Recombinant Human Midkine Protein
Catalog number: B2012868
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 ug
Molecular Weight or Concentration: 13.4 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Midkine Protein, Human, Recombinant
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Murasugi A. Efficient expression and purification of recombinant therapeutic protein candidates, human midkine and pleiotrophin Curr Pharm Biotechnol. 2013;14(8):768-84.
2: Cerezo-Wallis D, Contreras-Alcalde M, Troulé K, Catena X, Mucientes C, Calvo TG, Cañón E, Tejedo C, Pennacchi PC, Hogan S, Kölblinger P, Tejero H, Chen AX, Ibarz N, Graña-Castro O, Martinez L, Muñoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gómez-López G, Al-Shahrour F, Rabadán R, Levesque MP, Olmeda D, Soengas MS. Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state Nat Med. 2020 Dec;26(12):1865-1877.
3: Lu J, Liu QH, Wang F, Tan JJ, Deng YQ, Peng XH, Liu X, Zhang B, Xu X, Li XP. Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma J Exp Clin Cancer Res. 2018 Jul 13;37(1):147.
4: Murasugi A. Secretory expression of human protein in the Yeast Pichia pastoris by controlled fermentor culture Recent Pat Biotechnol. 2010 Jun;4(2):153-66.
5: Lackner I, Weber B, Baur M, Haffner-Luntzer M, Eiseler T, Fois G, Gebhard F, Relja B, Marzi I, Pfeifer R, Halvachizadeh S, Lipiski M, Cesarovic N, Pape HC, Kalbitz M; TREAT Research Group. Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism Front Immunol. 2019 Aug 21;10:1920.
6: Zhang ZH, Li HX, Qi YP, Du LJ, Zhu SY, Wu MY, Lu HL, Yu Y, Han W. Recombinant human midkine stimulates proliferation of articular chondrocytes Cell Prolif. 2010 Apr;43(2):184-94.
7: Xu C, Zhang Z, Wu M, Zhu S, Gao J, Zhang J, Yuan Y, Zhang K, Yu Y, Han W. Recombinant human midkine stimulates proliferation and decreases dedifferentiation of auricular chondrocytes in vitro Exp Biol Med (Maywood). 2011 Nov;236(11):1254-62.
8: Murasugi A, Tohma-Aiba Y. Production of native recombinant human midkine in the yeast, Pichia pastoris Protein Expr Purif. 2003 Feb;27(2):244-52.
9: Paul S, Mitsumoto T, Asano Y, Kato S, Kato M, Shinozawa T. Detection of truncated midkine in Wilms’ tumor by a monoclonal antibody against human recombinant truncated midkine Cancer Lett. 2001 Feb 26;163(2):245-51.
10: Murasugi A, Tohma-Aiba Y. Characterization of partially truncated human midkine expressed in Pichia pastoris Biosci Biotechnol Biochem. 2002 Jun;66(6):1295-300.

Products Related to Recombinant Human Midkine Protein can be found at Proteins