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Protease-Activated Receptor 4 Agonist

$595.00

Catalog Number: B2012502 (250 uL)
Protease-Activated Receptor 4 Agonist is a high quality selective protease-activated receptor 4 (PAR4) agonist. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2012502 Categories: , Tag:

Description

Protease-Activated Receptor 4 Agonist
Catalog number: B2012502
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 250 uL
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: PAR4
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yang J, Mapelli C, Wang Z, Sum CS, Hua J, Lawrence RM, Ni Y, Seiffert DA. An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay Platelets. 2022 Oct 3;33(7):979-986.
2: Fu Q, Cheng J, Gao Y, Zhang Y, Chen X, Xie J. Protease-activated receptor 4: a critical participator in inflammatory response Inflammation. 2015 Apr;38(2):886-95.
3: Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT. Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions Platelets. 2019;30(1):126-135.
4: Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins J Biol Chem. 2016 Aug 26;291(35):18453-64.
5: Barra A, Freitas KM, Marconato DG, Faria-Pinto P, Lopes MTP, Klein A. Protease-activated receptor 4 plays a role in lipopolysaccharide-induced inflammatory mechanisms in murine macrophages Naunyn Schmiedebergs Arch Pharmacol. 2021 May;394(5):853-862.
6: Kolpakov MA, Rafiq K, Guo X, Hooshdaran B, Wang T, Vlasenko L, Bashkirova YV, Zhang X, Chen X, Iftikhar S, Libonati JR, Kunapuli SP, Sabri A. Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury J Mol Cell Cardiol. 2016 Jan;90:21-9.
7: Augé C, Balz-Hara D, Steinhoff M, Vergnolle N, Cenac N. Protease-activated receptor-4 (PAR 4): a role as inhibitor of visceral pain and hypersensitivity Neurogastroenterol Motil. 2009 Nov;21(11):1189-e107.
8: Wadowski PP, Pultar J, Weikert C, Eichelberger B, Panzer B, Huber K, Lang IM, Koppensteiner R, Panzer S, Gremmel T. Protease-activated receptor-mediated platelet aggregation in acute coronary syndrome patients on potent P2Y(12) inhibitors Res Pract Thromb Haemost. 2019 May 22;3(3):383-390.
9: Chandrabalan A, Ramachandran R. Molecular mechanisms regulating Proteinase-Activated Receptors (PARs) FEBS J. 2021 Apr;288(8):2697-2726.
10: Sabri A, Guo J, Elouardighi H, Darrow AL, Andrade-Gordon P, Steinberg SF. Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinase J Biol Chem. 2003 Mar 28;278(13):11714-20.

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