PKA Inhibitor (5-24)

Product Description

PKA Inhibitor (5-24)
Catalog number: B2017239
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 µg
Molecular Weight or Concentration: 2222.4
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid, 2,2,2-trifluoroacetate Salt, PKI (5-24), Protein Kinase A Inhibitor (5-24)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Guergnon J, Dessauge F, Traincard F, Cayla X, Rebollo A, Bost PE, Langsley G, Garcia A. A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes Apoptosis. 2006 Aug;11(8):1263-73.
2: Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS. Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics J Pept Res. 1997 Mar;49(3):210-20.
3: Harrison DA, Carr DW, Meizel S. Involvement of protein kinase A and A kinase anchoring protein in the progesterone-initiated human sperm acrosome reaction Biol Reprod. 2000 Mar;62(3):811-20.
4: Hayabuchi Y, Davies NW, Standen NB. Angiotensin II inhibits rat arterial KATP channels by inhibiting steady-state protein kinase A activity and activating protein kinase Ce J Physiol. 2001 Jan 15;530(Pt 2):193-205.
5: Melamed P, Gur G, Elizur A, Rosenfeld H, Sivan B, Rentier-Delrue F, Yaron Z. Differential effects of gonadotropin-releasing hormone, dopamine and somatostatin and their second messengers on the mRNA levels of gonadotropin II beta subunit and growth hormone in the teleost fish, tilapia Neuroendocrinology. 1996 Oct;64(4):320-8.
6: Hilário-Souza E, Valverde RH, Britto-Borges T, Vieyra A, Lowe J. Golgi membranes from liver express an ATPase with femtomolar copper affinity, inhibited by cAMP-dependent protein kinase Int J Biochem Cell Biol. 2011 Mar;43(3):358-62.
7: Schurov IL, Hepworth TJ, Hastings MH. Dopaminergic signalling in the rodent neonatal suprachiasmatic nucleus identifies a role for protein kinase A and mitogen-activated protein kinase in circadian entrainment Eur J Neurosci. 2002 Jan;15(2):223-32.
8: Johnson BD, Brousal JP, Peterson BZ, Gallombardo PA, Hockerman GH, Lai Y, Scheuer T, Catterall WA. Modulation of the cloned skeletal muscle L-type Ca2+ channel by anchored cAMP-dependent protein kinase J Neurosci. 1997 Feb 15;17(4):1243-55.
9: Wörner R, Lukowski R, Hofmann F, Wegener JW. cGMP signals mainly through cAMP kinase in permeabilized murine aorta Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H237-44.
10: Gray PC, Tibbs VC, Catterall WA, Murphy BJ. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels J Biol Chem. 1997 Mar 7;272(10):6297-302.

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