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Human Osteoprotegerin (Recombinant)

$495.00

Catalog Number: B2010321 (10 ug)
Osteoprotegerin (Human, Recombinant) is a high quality research product used as highly pure Osteoprotegerin (Human, Recombinant) expressed in CHO. This protein acts as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) and is a member of the TNF receptor superfamily. Custom bulk orders of this product are available upon request.

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SKU: B2010321 Categories: , ,

Description

Osteoprotegerin (Human, Recombinant)
Catalog number: B2010321
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Osteoprotegerin (Human, Recombinant) expressed in CHO. This protein acts as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) and is a member of the TNF receptor superfamily.
Storage: -20C
Keywords: rHuOPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res
Ther. 2007;9 Suppl 1(Suppl 1):S1.

2: Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C. The Role of
Osteoprotegerin and Its Ligands in Vascular Function. Int J Mol Sci. 2019 Feb
6;20(3):705.

3: Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C. The role of
osteoprotegerin in the crosstalk between vessels and bone: Its potential utility
as a marker of cardiometabolic diseases. Pharmacol Ther. 2018 Feb;182:115-132.

4: Makarović S, Makarović Z, Steiner R, Mihaljević I, Milas-Ahić J.
Osteoprotegerin and Vascular Calcification: Clinical and Prognostic Relevance.
Coll Antropol. 2015 Jun;39(2):461-8.

5: Özkalaycı F, Gülmez Ö, Uğur-Altun B, Pandi-Perumal SR, Altun A. The Role of
Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the
Chicken or the Egg Paradox. Balkan Med J. 2018 May 29;35(3):225-232.

6: Valentini A, Cianfarani MA, Tarantino U, Di Daniele N, Bertoli A.
Osteoprotegerin as a biomarker of geriatric frailty syndrome. Aging (Albany NY).
2019 Jul 17;11(14):4900-4909.

7: Sasso GR, Florencio-Silva R, Simões RS, Baracat MC, Soares Júnior JM, Baracat
EC. Elevated serum osteoprotegerin levels in women: friend or foe? Rev Assoc Med
Bras (1992). 2015 Nov-Dec;61(6):524-9.

8: Weichhaus M, Chung ST, Connelly L. Osteoprotegerin in breast cancer: beyond
bone remodeling. Mol Cancer. 2015 Jun 10;14:117. doi: 10.1186/s12943-015-0390-5.
9: Jia D, Zhu Q, Liu H, Zuo C, He Y, Chen G, Lu A. Osteoprotegerin Disruption
Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT
Pathway Suppression. Circ Cardiovasc Genet. 2017 Feb;10(1):e001591.

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