[Nle8,18,Tyr34]-Parathyroid Hormone (Human, 3-34 Amide)

Product Description

[Nle8,18,Tyr34]-Parathyroid Hormone (Human, 3-34 Amide)
Catalog number: MDP0566
CAS Number: 148093-65-6
Sequence: Ser-Glu-Ile-Gln-Leu-Nle-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Nle-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2 (Nle: L-Norleucine)
Amount: 500 ug
Molecular Weight: 3910.4 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Singh AT, Kunnel JG, Strieleman PJ, Stern PH. Parathyroid hormone (PTH)-(1-34), [Nle(8,18),Tyr34]PTH-(3-34) amide, PTH-(1-31) amide, and PTH-related peptide-(1-34) stimulate phosphatidylcholine hydrolysis in UMR-106 osteoblastic cells: comparison with effects of phorbol 12,13-dibutyrate Endocrinology. 1999 Jan;140(1):131-7.
2: Nakai M, Fukase M, Yamaguchi T, Tsukamoto T, Fujii N, Fujita T. Human PTH-(3-34) inhibited the effects of human parathyroid hormone-related protein on phosphate uptake in a cultured renal cell line (OK cells) J Bone Miner Res. 1990 Oct;5(10):995-1002.
3: Born W, Loveridge N, Petermann JB, Kronenberg HM, Potts JT Jr, Fischer JA. Inhibition of parathyroid hormone bioactivity by human parathyroid hormone (PTH)-(3-84) and PTH-(8-84) synthesized in Escherichia coli Endocrinology. 1988 Oct;123(4):1848-53.
4: Schipani E, Karga H, Karaplis AC, Potts JT Jr, Kronenberg HM, Segre GV, Abou-Samra AB, Jüppner H. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor Endocrinology. 1993 May;132(5):2157-65.
5: Muff R, Caulfield MP, Fischer JA. Dissociation of cAMP accumulation and phosphate uptake in opossum kidney (OK) cells with parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) Peptides. 1990 Sep-Oct;11(5):945-9.
6: García-Ocaña A, De Miguel F, Peñaranda C, Albar JP, Sarasa JL, Esbrit P. Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth J Bone Miner Res. 1995 Dec;10(12):1875-84.
7: Lafond J, Auger D, Fortier J, Brunette MG. Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes Endocrinology. 1988 Dec;123(6):2834-40.
8: Kalinowski L, Dobrucki LW, Malinski T. Nitric oxide as a second messenger in parathyroid hormone-related protein signaling J Endocrinol. 2001 Aug;170(2):433-40.
9: Wright RD, Blair-West JR, Nelson JF, Tregear GW, Rosenblatt M. Evaluation of the biological properties of parathyroid hormone and analogues in a vascularly isolated parotid gland-based assay J Endocrinol. 1984 Sep;102(3):375-9.
10: Schlüter KD, Hellstern H, Wingender E, Mayer H. The central part of parathyroid hormone stimulates thymidine incorporation of chondrocytes J Biol Chem. 1989 Jul 5;264(19):11087-92.

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