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Human Neuroserpin (Recombinant, Human)

$595.00 $395.00

Catalog Number: B2010272 (10 ug)
Neuroserpin (Recombinant, Human) is a high quality research product used as highly pure human neuroserpin expressed in CHO cells. Neuroserpin acts as a serine protease inhibitor mainly produced in the nervous system. Custom bulk orders of this product are available upon request.

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SKU: B2010272 Categories: , ,

Description

Human Neuroserpin (Recombinant)
Catalog number: B2010272
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized powder
Appearance: Powder
Applications: highly pure human neuroserpin expressed in CHO cells. Neuroserpin acts as a serine protease inhibitor mainly produced in the nervous system.
Storage: -20C
Keywords: rHuNeuroserpin; Peptidase inhibitor 12; Serpin I1; SERPINI1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

References:
1: Lee TW, Tsang VW, Loef EJ, Birch NP. Physiological and pathological functions
of neuroserpin: Regulation of cellular responses through multiple mechanisms.
Semin Cell Dev Biol. 2017 Feb;62:152-159.

2: Roussel BD, Lomas DA, Crowther DC. Progressive myoclonus epilepsy associated
with neuroserpin inclusion bodies (neuroserpinosis). Epileptic Disord. 2016 Sep
1;18(S2):103-110.

3: Loef EJ, Brooks AES, Lorenz N, Birch NP, Dunbar PR. Neuroserpin regulates
human T cell-T cell interactions and proliferation through inhibition of tissue
plasminogen activator. J Leukoc Biol. 2020 Jan;107(1):145-158.

4: Adorjan I, Tyler T, Bhaduri A, Demharter S, Finszter CK, Bako M, Sebok OM,
Nowakowski TJ, Khodosevich K, Møllgård K, Kriegstein AR, Shi L, Hoerder-
Suabedissen A, Ansorge O, Molnár Z. Neuroserpin expression during human brain
development and in adult brain revealed by immunohistochemistry and single cell
RNA sequencing. J Anat. 2019 Sep;235(3):543-554.

5: Reumann R, Vierk R, Zhou L, Gries F, Kraus V, Mienert J, Romswinkel E,
Morellini F, Ferrer I, Nicolini C, Fahnestock M, Rune G, Glatzel M, Galliciotti
G. The serine protease inhibitor neuroserpin is required for normal synaptic
plasticity and regulates learning and social behavior. Learn Mem. 2017 Nov
15;24(12):650-659.

6: Visentin C, Broggini L, Sala BM, Russo R, Barbiroli A, Santambrogio C, Nonnis
S, Dubnovitsky A, Bolognesi M, Miranda E, Achour A, Ricagno S. Glycosylation
Tunes Neuroserpin Physiological and Pathological Properties. Int J Mol Sci. 2020
May 3;21(9):3235.

7: Moriconi C, Ordoñez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V,
Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E.
Interactions between N-linked glycosylation and polymerisation of neuroserpin
within the endoplasmic reticulum. FEBS J. 2015 Dec;282(23):4565-79.
8: Giampietro C, Lionetti MC, Costantini G, Mutti F, Zapperi S, La Porta CA.
Cholesterol impairment contributes to neuroserpin aggregation. Sci Rep. 2017 Mar
3;7:43669.

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