NeuGc Polyclonal Antibody Conjugated to R-Phycoerythrin

Description

NeuGc Polyclonal Antibody Conjugated to R-Phycoerythrin
Catalog number: B2010956
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 ug
Molecular Weight or Concentration: na
Supplied as: Solution
Applications: molecular tool for various immunological applications
Storage: -20°C
Keywords: Anti-NeuGc Polyclonal Antibody
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Bjerregaard-Andersen K, Abraha F, Johannesen H, Oscarson S, Moreno E, Krengel U. Key role of a structural water molecule for the specificity of 14F7-An antitumor antibody targeting the NeuGc GM3 ganglioside Glycobiology. 2021 Dec 18;31(11):1500-1509.
2: Lee W, Long C, Ramsoondar J, Ayares D, Cooper DK, Manji RA, Hara H. Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? Xenotransplantation. 2016 Sep;23(5):370-80.
3: Lee W, Miyagawa Y, Long C, Ekser B, Walters E, Ramsoondar J, Ayares D, Tector AJ, Cooper DK, Hara H. Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation Cornea. 2016 Jan;35(1):105-13.
4: Talavera A, Eriksson A, Okvist M, López-Requena A, Fernández-Marrero Y, Pérez R, Moreno E, Krengel U. Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody Mol Immunol. 2009 Oct;46(16):3466-75.
5: Sanai Y, Yamasaki M, Nagai Y. Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc) Biochim Biophys Acta. 1988 Feb 19;958(3):368-74.
6: He D, Fan X, Liu B, Tian Y, Zhang X, Kang L, Tai Y, Liu S, Wang Q, Li Q, Cai J. Generation and characterization of a IgG monoclonal antibody specific for GM3 (NeuGc) ganglioside by immunizing β3Gn-T5 knockout mice Sci Rep. 2018 Feb 7;8(1):2561.
7: Rodríguez M, Llanes L, Pérez A, Pérez R, Vázquez AM. Generation and characterization of an anti-idiotype monoclonal antibody related to GM3(NeuGc) ganglioside Hybrid Hybridomics. 2003 Oct;22(5):307-14.
8: Gabri MR, Otero LL, Gomez DE, Alonso DF. Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines J Exp Clin Cancer Res. 2009 Dec 1;28(1):146.
9: Bousquet PA, Sandvik JA, Jeppesen Edin NF, Krengel U. Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute Biochem Biophys Res Commun. 2018 Jan 1;495(1):1562-1566.
10: Nakamura K, Suzuki M, Taya C, Inagaki F, Yamakawa T, Suzuki A. A sialidase-susceptible ganglioside, IV3 alpha(NeuGc alpha 2-8NeuGc)-Gg4Cer, is a major disialoganglioside in WHT/Ht mouse thymoma and thymocytes J Biochem. 1991 Nov;110(5):832-41.

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