MK2a Inhibitor (Highly Pure)


Catalog Number: B2012568 (1 mg)
MK2a Inhibitor (Highly Pure) is a high quality substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of MAPKAPK-2 (MK2). This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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MK2a Inhibitor (Highly Pure)
Catalog number: B2012568
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 349.4 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: CMPD 1, 2′-fluoro-N-(4-hydroxyphenyl)-[1,1′-biphenyl]-4-butanamide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Brugnano J, McMasters J, Panitch A. Characterization of endocytic uptake of MK2-inhibitor peptides J Pept Sci. 2013 Oct;19(10):629-38.
2: Ronkina N, Kotlyarov A, Gaestel M. MK2 and MK3–a pair of isoenzymes? Front Biosci. 2008 May 1;13:5511-21.
3: Brugnano JL, Panitch A. Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides PLoS One. 2014 Jan 6;9(1):e84821.
4: Hugon J, Paquet C. The PKR/P38/RIPK1 Signaling Pathway as a Therapeutic Target in Alzheimer’s Disease Int J Mol Sci. 2021 Mar 19;22(6):3136.
5: Chen IT, Chen HC, Lo YH, Lai PY, Hsieh FY, Wu YH, Shih HM, Lai MZ. Promyelocytic leukemia protein targets MK2 to promote cytotoxicity EMBO Rep. 2021 Dec 6;22(12):e52254.
6: Fujino A, Fukushima K, Namiki N, Kosugi T, Takimoto-Kamimura M. Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800 Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):80-7.
7: Duraisamy S, Bajpai M, Bughani U, Dastidar SG, Ray A, Chopra P. MK2: a novel molecular target for anti-inflammatory therapy Expert Opin Ther Targets. 2008 Aug;12(8):921-36.
8: Ruiz M, Coderre L, Allen BG, Des Rosiers C. Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1914-1922.
9: Ray AL, Berggren KL, Restrepo Cruz S, Gan GN, Beswick EJ. Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth Int J Cancer. 2018 Apr 15;142(8):1702-1711.
10: Gordon D, Hellriegel ET, Hope HR, Burt D, Monahan JB. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study Clin Pharmacol. 2021 Jun 10;13:123-134.

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