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Lactacystin from Streptomyces spp.

$795.00

Catalog Number: B2010434 (0.2 mg)
Lactacystin from Streptomyces spp. is a highly pure Lactacystin from Streptomyces spp. This compound has antibiotic properties as well as proteasome inhibitory properties. Custom bulk orders of this product are available upon request.
Live Enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2010434 Category:

Description

Lactacystin from Streptomyces spp.
Catalog number: B2010434
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.2 mg
Molecular Weight or Concentration: 376.43
Supplied as: Powder
Appearance: Powder
Applications: Highly pure Lactacystin from Streptomyces spp. This compound has antibiotic properties as well as proteasome inhibitory properties.
Storage: -20C
Keywords: Lactacystin
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ōmura S, Crump A. Lactacystin: first-in-class proteasome inhibitor still
excelling and an exemplar for future antibiotic research. J Antibiot (Tokyo).
2019 Apr;72(4):189-201.

2: Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P,
Tothova L, Vrankova S, Balazova L, Zorad S, Adamcova M. Lactacystin-Induced
Model of Hypertension in Rats: Effects of Melatonin and Captopril. Int J Mol
Sci. 2017 Jul 25;18(8):1612.

3: Tomoda H, Omura S. Lactacystin, a proteasome inhibitor: discovery and its
application in cell biology. Yakugaku Zasshi. 2000 Oct;120(10):935-49.

4: Fenteany G, Schreiber SL. Lactacystin, proteasome function, and cell fate. J
Biol Chem. 1998 Apr 10;273(15):8545-8.

5: Shibasaki M, Kanai M, Fukuda N. Total synthesis of lactacystin and
salinosporamide A. Chem Asian J. 2007 Jan 8;2(1):20-38.

6: Ito Y, Fukushima H, Katagiri T, Seo Y, Hirata S, Zhang M, Hosokawa R, Jimi E.
Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic
differentiation by increasing active Smads. Biochem Biophys Res Commun. 2011 Apr
1;407(1):225-9.

7: Legnani FG, Pradilla G, Thai QA, Fiorindi A, Recinos PF, Tyler BM, Gaini SM,
DiMeco F, Brem H, Olivi A. Lacta_cystin exhibits potent anti-tumor activity in an
animal model of malignant glioma when administered via controlled-release
polymers. J Neurooncol. 2006 May;77(3):225-32.

8: Perez-Alvarez S, Solesio ME, Manzanares J, Jordán J, Galindo MF. Lacta_cystin
requires reactive oxygen species and Bax redistribution to induce mitochondria-
mediated cell death. Br J Pharmacol. 2009 Oct;158(4):1121-30.

9: Zhu W, Xie W, Pan T, Xu P, Fridkin M, Zheng H, Jankovic J, Youdim MB, Le W.
Prevention and restoration of lacta_cystin-induced nigrostriatal dopamine neuron
degeneration by novel brain-permeable iron chelators. FASEB J. 2007
Dec;21(14):3835-44.
10: Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N’Kuli F, Courtoy PJ,
Octave JN. Lactacystin decreases amyloid-beta peptide production by inhibiting
beta-secretase activity. J Neurosci Res. 2006 Nov 1;84(6):1311-22.

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