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Interleukin-21 (Human, Recombinant)

$695.00 $495.00

Catalog Number: B2010308 (10 ug)
Interleukin-21 (Human, Recombinant) is a high quality research product used as highly pure Interleukin-21 (Human, Recombinant) expressed in E. coli. This protein acts as a class 1 cytokine produced by activated CD4+ T cells. This protein stimulates T cells, B cells and NK cells, leading to enhanced proliferation and mature effector function. Custom bulk orders of this product are available upon request.

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SKU: B2010308 Categories: , ,

Description

Interleukin-21 (Human, Recombinant)
Catalog number: B2010308
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Interleukin-21 (Human, Recombinant) expressed in E. coli. This protein acts as a class 1 cytokine produced by activated CD4+ T cells. This protein stimulates T cells, B cells and NK cells, leading to enhanced proliferation and mature effector function.
Storage: -20C
Keywords: rHuIL-21; Za11; IL21
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic
potential. Nat Rev Drug Discov. 2014 May;13(5):379-95.

2: Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M,
Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K,
Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, Nakaoka Y.
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of
pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May
19;112(20):E2677-86.

3: Solaymani-Mohammadi S, Eckmann L, Singer SM. Interleukin (IL)-21 in
Inflammation and Immunity During Parasitic Diseases. Front Cell Infect
Microbiol. 2019 Dec 4;9:401.

4: Tangye SG, Ma CS. Regulation of the germinal center and humoral immunity by
interleukin-21. J Exp Med. 2020 Jan 6;217(1):e20191638.

5: Long D, Chen Y, Wu H, Zhao M, Lu Q. Clinical significance and immunobiology
of IL-21 in autoimmunity. J Autoimmun. 2019 May;99:1-14.

6: Paidipally P, Tripathi D, Van A, Radhakrishnan RK, Dhiman R,
Venkatasubramanian S, Devalraju KP, Tvinnereim AR, Valluri VL, Vankayalapati R.
Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium
tuberculosis Infection. J Infect Dis. 2018 Mar 28;217(8):1323-1333.

7: Vallières F, Durocher I, Girard D. Biological activities of interleukin
(IL)-21 in human monocytes and macrophages. Cell Immunol. 2019 Mar;337:62-70.

8: Khattar M, Baum CE, Schroder P, Breidenbach JD, Haller ST, Chen W, Stepkowski
S. Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in
murine heart allograft rejection. PLoS One. 2019 Nov 22;14(11):e0225624.

9: Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, Yin L, Liu
L, Hackert T, Giese T, Herr I, Gaida MM. Interleukin 21 Receptor/Ligand
Interaction Is Linked to Disease Progression in Pancreatic Cancer. Cells. 2019
Sep 18;8(9):1104.
10: Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA,
Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C,
Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly
K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching
A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD,
Foster D. Interleukin 21 and its receptor are involved in NK cell expansion and
regulation of lymphocyte function. Nature. 2000 Nov 2;408(6808):57-63.

Products Related to Interleukin-21 (Human, Recombinant) : Proteins

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