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Insulin-like Growth Factor-Binding Protein 3 (Human)

$595.00 $395.00

Catalog Number: B2010280 (10 ug)
Insulin-like Growth Factor-Binding Protein 3 (Human) is a high quality research product used as highly pure Insulin-like Growth Factor-Binding Protein 3 (Human) expressed in E. coli. This protein acts as as a protein that prolongs the half-life of the insulin-like growth factors and inhibits the interaction of IGFs with their cell surface receptors. Custom bulk orders of this product are available upon request.

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SKU: B2010280 Categories: , ,

Description

Insulin-like Growth Factor-Binding Protein 3 (Human)
Catalog number: B2010280
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Insulin-like Growth Factor-Binding Protein 3 (Human) expressed in E. coli. This protein acts as as a protein that prolongs the half-life of the insulin-like growth factors and inhibits the interaction of IGFs with their cell surface receptors.
Storage: -20C
Keywords: rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ranke MB. Insulin-like growth factor binding-protein-3 (IGFBP-3). Best Pract
Res Clin Endocrinol Metab. 2015 Oct;29(5):701-11.

2: Price D, Muterspaugh R, Clegg B, Williams A, Stephens A, Guthrie J, Heyl D,
Evans HG. IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased
Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent
Manner. Sci Rep. 2020 Mar 19;10(1):5083.

3: Scully T, Scott CD, Firth SM, Sedger LM, Pintar JE, Twigg SM, Baxter RC.
Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell
accumulation. Endocr Relat Cancer. 2018 Feb;25(2):111-122.

4: Johnson MA, Firth SM. IGFBP-3: a cell fate pivot in cancer and disease.
Growth Horm IGF Res. 2014 Oct;24(5):164-73.

5: Tan VY, Biernacka KM, Dudding T, Bonilla C, Gilbert R, Kaplan RC, Qibin Q,
Teumer A, Martin RM, Perks CM, Timpson NJ, Holly JMP; PRACTICAL consortium.
Reassessing the Association between Circulating Vitamin D and IGFBP-3:
Observational and Mendelian Randomization Estimates from Independent Sources.
Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1462-1471.

6: Zhang Q, Jiang Y, Steinle JJ. IGFBP-3 reduces eNOS and PKCzeta
phosphorylation, leading to lowered VEGF levels. Mol Vis. 2015 May 22;21:604-11.

7: Agostini-Dreyer A, Jetzt AE, Stires H, Cohick WS. Endogenous IGFBP-3 Mediates
Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear
Export. Endocrinology. 2015 Nov;156(11):4141-51.

8: Alkharobi H, Alhodhodi A, Hawsawi Y, Alkafaji H, Devine D, El-Gendy R,
Beattie J. IGFBP-2 and -3 co-ordinately regulate IGF1 induced matrix
mineralisation of differentiating human dental pulp cells. Stem Cell Res. 2016
Nov;17(3):517-522.
9: Nguyen KH, Mishra S, Nyomba BL. In vitro differentiation of mouse brown
preadipocytes is enhanced by IGFBP-3 expression and reduced by IGFBP-3
silencing. Obesity (Silver Spring). 2015 Oct;23(10):2083-92.

Products Related to Insulin-like Growth Factor-Binding Protein 3 (Human) : Proteins

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