Human Tyrosyl-DNA Phosphodiesterase 1


Catalog Number: B2012410 (5 ug)
Human Tyrosyl-DNA Phosphodiesterase 1 is a high quality Human Tyrosyl-DNA Phosphodiesterase 1 expressed in Sf9 insect cells. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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Human Tyrosyl-DNA Phosphodiesterase 1
Catalog number: B2012410
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 ug
Molecular Weight or Concentration: 69.5 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Tyr-DNA phosphodiesterase 1, TDP1, FLJ11090, MGC104252
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Dyrkheeva N, Anarbaev R, Lebedeva N, Kuprushkin M, Kuznetsova A, Kuznetsov N, Rechkunova N, Lavrik O. Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols Front Cell Dev Biol. 2020 Dec 23;8:604732.
2: Iyama T, Wilson DM 3rd. DNA repair mechanisms in dividing and non-dividing cells DNA Repair (Amst). 2013 Aug;12(8):620-36.
3: Rechkunova NI, Lebedeva NA, Lavrik OI. [Tyrosyl-DNA Phosphodiesterase 1 Is a New Player in Repair of Apurinic/Apyrimidinic Sites] Bioorg Khim. 2015 Sep-Oct;41(5):531-8.
4: Zakharenko AL, Drenichev MS, Dyrkheeva NS, Ivanov GA, Oslovsky VE, Ilina ES, Chernyshova IA, Lavrik OI, Mikhailov SN. Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides Molecules. 2020 Aug 13;25(16):3694.
5: Zakharenko A, Dyrkheeva N, Lavrik O. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity Med Res Rev. 2019 Jul;39(4):1427-1441.
6: Pommier Y, Sun Y, Huang SN, Nitiss JL. Roles of eukaryotic topoisomerases in transcription, replication and genomic stability Nat Rev Mol Cell Biol. 2016 Nov;17(11):703-721.
7: Lebedeva NA, Rechkunova NI, El-Khamisy SF, Lavrik OI. Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites Biochimie. 2012 Aug;94(8):1749-53.
8: Huang SN, Pommier Y, Marchand C. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Expert Opin Ther Pat. 2011 Sep;21(9):1285-92.
9: Beretta GL, Cossa G, Gatti L, Zunino F, Perego P. Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment Curr Med Chem. 2010;17(15):1500-8.
10: Laev SS, Salakhutdinov NF, Lavrik OI. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027.

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