Human Thromboxane A Synthase


Catalog Number: B2013161 (50 ug)
Human Thromboxane A Synthase is a high quality recombinant Human Thromboxane A Synthase produced in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human Thromboxane A Synthase
Catalog number: B2013161
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 ug
Molecular Weight or Concentration: 59.1 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: CYP5A1, Cytochrome P450 5A1, TBXAS1, TXAS, TXA Synthase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Mesitskaya DF, Syrkin AL, Aksenova MG, Zhang Y, Zamyatnin AA Jr, Kopylov PY. Thromboxane A Synthase: A New Target for the Treatment of Cardiovascular Diseases Cardiovasc Hematol Agents Med Chem. 2018;16(2):81-87.
2: Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T. Molecular cloning of human platelet thromboxane A synthase Biochem Biophys Res Commun. 1991 Aug 15;178(3):1479-84.
3: Kontogiorgis C, Hadjipavlou-Litina D. Thromboxane synthase inhibitors and thromboxane A2 receptor antagonists: a quantitative structure activity relationships (QSARs) analysis Curr Med Chem. 2010;17(28):3162-214.
4: Cathcart MC, Reynolds JV, O’Byrne KJ, Pidgeon GP. The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer Biochim Biophys Acta. 2010 Apr;1805(2):153-66.
5: Ashton AW, Zhang Y, Cazzolli R, Honn KV. The Role and Regulation of Thromboxane A(2) Signaling in Cancer-Trojan Horses and Misdirection Molecules. 2022 Sep 22;27(19):6234.
6: Sathler PC, Santana M, Lourenço AL, Rodrigues CR, Abreu P, Cabral LM, Castro HC. Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel J Enzyme Inhib Med Chem. 2014 Aug;29(4):527-31.
7: Ekambaram P, Lambiv W, Cazzolli R, Ashton AW, Honn KV. The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis Cancer Metastasis Rev. 2011 Dec;30(3-4):397-408.
8: Matsunobu T, Okuno T, Yokoyama C, Yokomizo T. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand J Lipid Res. 2013 Nov;54(11):2979-87.
9: Ershov PV, Yablokov E, Zgoda V, Mezentsev Y, Gnedenko O, Kaluzhskiy L, Svirid A, Gilep A, Usanov SA, Ivanov A. A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases Cell Biol Int. 2021 Jun;45(6):1175-1182.
10: Ohashi K, Ruan KH, Kulmacz RJ, Wu KK, Wang LH. Primary structure of human thromboxane synthase determined from the cDNA sequence J Biol Chem. 1992 Jan 15;267(2):789-93.

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