SPARC Protein (Human Recombinant)
Catalog Number: B2010370 (10 ug)
Human SPARC is a high quality research product used as highly pure Human SPARC expressed in E. coli. This protein acts as a Ca+2-binding glycoprotein associated with morphogenesis, remodeling, cellular migration, and proliferation. Custom bulk orders of this product are available upon request.
Catalog number: B2010370
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Applications: highly pure Human SPARC expressed in E. coli. This protein acts as a Ca+2-binding glycoprotein associated with morphogenesis, remodeling, cellular migration, and proliferation.
Keywords: rHuSPARC; BM-40; Osteonectin
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
1: Rosset EM, Bradshaw AD. SPARC/osteonectin in mineralized tissue. Matrix Biol.
2: Wong SL, Sukkar MB. The SPARC protein: an overview of its role in lung cancer
and pulmonary fibrosis and its potential role in chronic airways disease. Br J
Pharmacol. 2017 Jan;174(1):3-14.
3: Li T, Tan X, Zhu S, Zhong W, Huang B, Sun J, Li F, Wang Y. SPARC induces
phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-
mediated autophagy. Neurosci Lett. 2019 Nov 1;712:134485.
4: Workman G, Bradshaw AD. Production and purification of recombinant human
SPARC. Methods Cell Biol. 2018;143:335-345.
5: Sangaletti S, Talarico G, Chiodoni C, Cappetti B, Botti L, Portararo P,
Gulino A, Consonni FM, Sica A, Randon G, Di Nicola M, Tripodo C, Colombo MP.
SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive
Activities. Front Immunol. 2019 Jun 20;10:1369.
6: Chern YJ, Wong JCT, Cheng GSW, Yu A, Yin Y, Schaeffer DF, Kennecke HF, Morin
G, Tai IT. The interaction between SPARC and GRP78 interferes with ER stress
signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal
cancer. Cell Death Dis. 2019 Jun 26;10(7):504.
7: Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C,
Workman G, Weaver M, Sage EH, Barres BA, Eroglu C. Control of excitatory CNS
synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proc Natl Acad
Sci U S A. 2011 Aug 9;108(32):E440-9.
8: Nagaraju GP, Dontula R, El-Rayes BF, Lakka SS. Molecular mechanisms
underlying the divergent roles of SPARC_ in human carcinogenesis. Carcinogenesis.
9: Xu J, Yang S, Gu X, Shen H, Wang L, Xu W, Fang L, Mao Y, Xu L, Chen Y, Fan W,
Wang J. SPARC correlates with unfavorable outcome and promotes tumor growth in
lung squamous cell carcinoma. Exp Mol Pathol. 2019 Oct;110:104276.
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