Human Recombinant 2B4/CD244 Extracellular Domain

Product Description

Human Recombinant 2B4/CD244 Extracellular Domain
Catalog number: B2016943
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 23.8 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Cluster of Differentiation 244, NAIL, Natural Killer Cell Receptor 2B4, NK Cell Activation-inducing Ligand, NKR2B4, Nmrk, SLAM Family Member 4, SLAMF4
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms Eur J Immunol. 2009 Jun;39(6):1632-41.
2: Altvater B, Landmeier S, Pscherer S, Temme J, Schweer K, Kailayangiri S, Campana D, Juergens H, Pule M, Rossig C. 2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells Clin Cancer Res. 2009 Aug 1;15(15):4857-66.
3: Mathew SO, Kumaresan PR, Lee JK, Huynh VT, Mathew PA. Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells J Immunol. 2005 Jul 15;175(2):1005-13.
4: Altvater B, Landmeier S, Pscherer S, Temme J, Juergens H, Pule M, Rossig C. 2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T cells Cancer Immunol Immunother. 2009 Dec;58(12):1991-2001.
5: Messmer B, Eissmann P, Stark S, Watzl C. CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells J Immunol. 2006 Apr 15;176(8):4646-50.
6: Margraf-Schönfeld S, Böhm C, Watzl C. Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein J Biol Chem. 2011 Jul 8;286(27):24142-9.
7: Eissmann P, Beauchamp L, Wooters J, Tilton JC, Long EO, Watzl C. Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244) Blood. 2005 Jun 15;105(12):4722-9.
8: Kubin MZ, Parshley DL, Din W, Waugh JY, Davis-Smith T, Smith CA, Macduff BM, Armitage RJ, Chin W, Cassiano L, Borges L, Petersen M, Trinchieri G, Goodwin RG. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48 Eur J Immunol. 1999 Nov;29(11):3466-77.
9: Brown MH, Boles K, van der Merwe PA, Kumar V, Mathew PA, Barclay AN. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48 J Exp Med. 1998 Dec 7;188(11):2083-90.
10: Bida AT, Upshaw Neff JL, Dick CJ, Schoon RA, Brickshawana A, Chini CC, Billadeau DD. 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis Mol Immunol. 2011 May;48(9-10):1149-59.

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