Human Recombinant 15-Lipoxygenase-2

Description

Human Recombinant 15-Lipoxygenase-2
Catalog number: B2012896
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 76 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: 15-LOX-2, 15-LO-2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tang DG, Bhatia B, Tang S, Schneider-Broussard R. 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size) Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):135-46.
2: Yang L, Ma C, Zhang L, Zhang M, Li F, Zhang C, Yu X, Wang X, He S, Zhu D, Song Y. 15-Lipoxygenase-2/15(S)-hydroxyeicosatetraenoic acid regulates cell proliferation and metastasis via the STAT3 pathway in lung adenocarcinoma Prostaglandins Other Lipid Mediat. 2018 Sep;138:31-40.
3: Droege KD, Keithly ME, Sanders CR, Armstrong RN, Thompson MK. Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange Biochemistry. 2017 Sep 26;56(38):5065-5074.
4: Kobe MJ, Neau DB, Mitchell CE, Bartlett SG, Newcomer ME. The structure of human 15-lipoxygenase-2 with a substrate mimic J Biol Chem. 2014 Mar 21;289(12):8562-9.
5: Vaezi MA, Safizadeh B, Eghtedari AR, Ghorbanhosseini SS, Rastegar M, Salimi V, Tavakoli-Yaraki M. 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword Lipids Health Dis. 2021 Nov 27;20(1):169.
6: Roffeis J, Hornung D, Kuhn H, Walther M. 15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary Eur J Cancer Prev. 2007 Dec;16(6):568-75.
7: Green AR, Barbour S, Horn T, Carlos J, Raskatov JA, Holman TR. Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential Biochemistry. 2016 May 24;55(20):2832-40.
8: Hultén LM, Olson FJ, Aberg H, Carlsson J, Karlström L, Borén J, Fagerberg B, Wiklund O. 15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1alpha Eur J Clin Invest. 2010 Jan;40(1):11-7.
9: Danielsson KN, Rydberg EK, Ingelsten M, Akyürek LM, Jirholt P, Ullström C, Forsberg GB, Borén J, Wiklund O, Hultén LM. 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration Atherosclerosis. 2008 Jul;199(1):34-40.
10: Shappell SB, Keeney DS, Zhang J, Page R, Olson SJ, Brash AR. 15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa J Invest Dermatol. 2001 Jul;117(1):36-43.

Products Related to Human Recombinant 15-Lipoxygenase-2 can be found at Enzymes