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Human Noggin (Recombinant Protein)

$695.00 $495.00

Catalog Number: B2010319 (10 ug)
Human Noggin (Human, Recombinant) is a high quality research product used as highly pure Human Noggin (Human, Recombinant) expressed in CHO. This protein acts as an antagonist of bone morphogenetic proteins (BMPs) and binds with high affinity to hBMP-4. Recombinant Human Noggin is essential for proper skeletal development. Custom bulk orders of this product are available upon request.

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SKU: B2010319 Categories: , ,

Description

Human Noggin (Recombinant)
Catalog number: B2010319
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Noggin (Human, Recombinant) expressed in CHO. This protein acts as an antagonist of bone morphogenetic proteins (BMPs) and binds with high affinity to hBMP-4. Recombinant Human Noggin is essential for proper skeletal development.
Storage: -20C
Keywords: rHuNoggin; NOG
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes
L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI.
Noggin depletion in adipocytes promotes obesity in mice. Mol Metab. 2019
Jul;25:50-63.

2: Jani P, Zhang H, Benson MD, Qin C. Noggin inhibition of mouse dentinogenesis.
J Oral Biosci. 2020 Mar;62(1):72-79.

3: Hashimi SM. Exogenous noggin binds the BMP-2 receptor and induces alkaline
phosphatase activity in osteoblasts. J Cell Biochem. 2019
Aug;120(8):13237-13242.

4: Sun Z, Gao X, Zabkiewicz C, Ruge F, Xie M, Cai S, Sun PH, Griffiths P, Pugh
MR, Ji J, Jiang WG, Ye L. Noggin is associated with a poor prognosis of gastric
cancer by promoting the proliferation of gastric cancer cells via the
upregulation of EGFR. Int J Oncol. 2020 Sep;57(3):813-824.

5: Anastasilakis AD, Polyzos SA, Makras P, Rauner M, Sonnleitner L, Hawa G,
Tsourdi E, Yavropoulou MP, Missbichler A, Terpos E. Circulating noggin levels
following treatment with denosumab or teriparatide in postmenopausal women with
low bone mass. J Musculoskelet Neuronal Interact. 2019 Sep 1;19(3):253-257.

6: Polyzos SA, Kountouras J, Anastasilakis AD, Makras P, Hawa G, Sonnleitner L,
Missbichler A, Doulberis M, Katsinelos P, Terpos E. Noggin levels in
nonalcoholic fatty liver disease: the effect of vitamin E treatment. Hormones
(Athens). 2018 Dec;17(4):573-579.

7: Ghadakzadeh S, Hamdy RC, Tabrizian M. Efficient in vitro delivery of
Noggin siRNA enhances osteoblastogenesis. Heliyon. 2017 Nov 13;3(11):e00450.

8: Xia CP, Pan T, Zhang N, Guo JR, Yang BW, Zhang D, Li J, Xu K, Meng Z, He H.
Sp1 promotes dental pulp stem cell osteoblastic differentiation through
regulating noggin. Mol Cell Probes. 2020 Apr;50:101504.
9: Ermakova GV, Kucheryavyy AV, Zaraisky AG, Bayramov AV. Discovery of four
Noggin genes in lampreys suggests two rounds of ancient genome duplication.
Commun Biol. 2020 Sep 10;3(1):501.

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