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Interleukin-6 (IL-6, Human, Recombinant)

$495.00

Catalog Number: B2010262 (10 ug)
Human Interleukin-6 (IL-6) is a high quality research product used as highly pure recombinant human Interleukin 6 (expressed in CHO cells). IL-6 is a 26-kD protein produced by fibroblasts, T lymphocytes, endothelial cells, monocytes, and keratinocytes during an inflammation response. Custom bulk orders of this product are available upon request.

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SKU: B2010262 Categories: , ,

Description

 Interleukin-6 (IL-6, Human, Recombinant)
Catalog number: B2010262
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: highly pure recombinant human Interleukin 6 (expressed in CHO cells). IL-6 is a 26-kD protein produced by fibroblasts, T lymphocytes, endothelial cells, monocytes, and keratinocytes during an inflammation response.
Storage: -20C
Keywords: IL-6, rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

References:
1: Schmidt-Arras D, Rose-John S. IL-6 pathway in the liver: From physiopathology
to therapy. J Hepatol. 2016 Jun;64(6):1403-15.

2: Kumari N, Dwarakanath BS, Das A, Bhatt AN. Role of interleukin-6 in cancer
progression and therapeutic resistance. Tumour Biol. 2016 Sep;37(9):11553-11572.

3: Jordan SC, Choi J, Kim I, Wu G, Toyoda M, Shin B, Vo A. Interleukin-6, A
Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft
Rejection: Therapeutic Implications of IL-6 Receptor Blockade. Transplantation.
2017 Jan;101(1):32-44.

4: Yao X, Huang J, Zhong H, Shen N, Faggioni R, Fung M, Yao Y. Targeting
interleukin-6 in inflammatory autoimmune diseases and cancers. Pharmacol Ther.
2014 Feb;141(2):125-39.

5: Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. IL-6/IL-6 receptor
system and its role in physiological and pathological conditions. Clin Sci
(Lond). 2012 Feb;122(4):143-59.

6: Aparicio-Siegmund S, Deseke M, Lickert A, Garbers C. Trans-signaling of
interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by
soluble CD5. Biochem Biophys Res Commun. 2017 Mar 18;484(4):808-812. d

7: Blanchetot C, De Jonge N, Desmyter A, Ongenae N, Hofman E, Klarenbeek A, Sadi
A, Hultberg A, Kretz-Rommel A, Spinelli S, Loris R, Cambillau C, de Haard H.
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6)
Antibodies. J Biol Chem. 2016 Jun 24;291(26):13846-54.

8: Nilsonne G, Lekander M, Åkerstedt T, Axelsson J, Ingre M. Diurnal Variation
of Circulating Interleukin-6 in Humans: A Meta-Analysis. PLoS One. 2016 Nov
10;11(11):e0165799.

9: Peng J, Guan J, Yao H, Jin X. Magnetic colorimetric immunoassay for human
interleukin-6 based on the oxidase activity of ceria spheres. Anal Biochem. 2016
Jan 1;492:63-8.

10: Chouman K, Korioth-Schmitz B, Sack M, Schmitz JE, Pham AT, Fischer R, Barth
S, Klockenbring T, Fendel R. Characterization of new anti-IL-6 antibodies
revealed high potency candidates for intracellular cytokine detection and
specific targeting of IL-6 receptor binding sites. Eur Cytokine Netw. 2018 Jun
1;29(2):59-72.

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