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Human Interferon-alpha2b (Highly Pure)

$395.00

Catalog Number: B2010283 (10 ug)
Human Interferon-alpha2b (Highly Pure) is a high quality research product used as highly pure Human Interferon-alpha2b (Highly Pure) expressed in HEK 293 cells. This protein acts as a regulatory mediator of the immune response with established antiviral and antitumor activities. Custom bulk orders of this product are available upon request.

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SKU: B2010283 Categories: ,

Description

Human Interferon-alpha2b (Highly Pure)
Catalog number: B2010283
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Interferon-alpha2b (Highly Pure) expressed in HEK 293 cells. This protein acts as a regulatory mediator of the immune response with established antiviral and antitumor activities.
Storage: -20C
Keywords: rHuIFN-α2b; IFNA; INFA2; IFN-a 2b
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ishikawa T, Higuchi K, Kubota T, Seki K, Honma T, Yoshida T, Kamimura T.
Combination PEG-IFN a-2b/ribavirin therapy following treatment of hepatitis C
virus-associated hepatocellular carcinoma is capable of improving hepatic
functional reserve and survival. Hepatogastroenterology. 2012 Mar-
Apr;59(114):529-32.

2: Rustgi VK. Albinterferon alfa-2b, a novel fusion protein of human albumin and
human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009
Apr;25(4):991-1002.

3: Alimena G, Morra E, Lazzarino M, Liberati AM, Montefusco E, Inverardi D,
Bernasconi P, Mancini M, Donti E, Grignani F, et al. Interferon alpha-2b as
therapy for Ph’-positive chronic myelogenous leukemia: a study of 82 patients
treated with intermittent or daily administration. Blood. 1988 Aug;72(2):642-7.

4: Subramanian GM, Fiscella M, Lamousé-Smith A, Zeuzem S, McHutchison JG.
Albinterferon alpha-2b: a genetic fusion protein for the treatment of chronic
hepatitis C. Nat Biotechnol. 2007 Dec;25(12):1411-9.

5: Umemoto S, Haruta M, Sakisaka M, Ikeda T, Tsukamoto H, Komohara Y, Takeya M,
Nishimura Y, Senju S. Cancer therapy with major histocompatibility complex-
deficient and interferon β-producing myeloid cells derived from allogeneic
embryonic stem cells. Cancer Sci. 2019 Oct;110(10):3027-3037.

6: Aruna, Li L. Anti-Interferon Alpha Antibodies in Patients with High-Risk
BCR/ABL-Negative Myeloproliferative Neoplasms Treated with Recombinant Human
Interferon-α. Med Sci Monit. 2018 Apr 17;24:2302-2309.

7: Mitchell MS. Immunotherapy as part of combinations for the treatment of
cancer. Int Immunopharmacol. 2003 Aug;3(8):1051-9.

8: Kumar L, Gangadharan VP, Rao DR, Saikia T, Shah S, Malhotra H, Bapsy PP,
Singh K, Rao R. Safety and efficacy of an indigenous recombinant interferon-
alpha-2b in patients with chronic myelogenous leukaemia: results of a
multicentre trial from India. Natl Med J India. 2005 Mar-Apr;18(2):66-70.

9: Lagra F, Raptopoulou-Gigi M, Orphanou-Koumerkeridou H, Goulis G. In vitro
effect of interferon alpha-2b on T lymphocyte transformation and leukocyte
migration inhibition in patients with chronic brucellosis. Immunopharmacol
Immunotoxicol. 1989;11(2-3):223-32.

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