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Human Interferon-alpha2a (Highly Pure)

$395.00

Catalog Number: B2010282 (10 ug)
Human Interferon-alpha2a (Highly Pure) is a high quality research product used as highly pure Human Interferon-alpha2a (Highly Pure) expressed in E. coli. This protein acts as a regulatory mediator of the immune response with demonstrated antiviral and antitumor activities. Custom bulk orders of this product are available upon request.

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SKU: B2010282 Categories: ,

Description

Human Interferon-alpha2a (Highly Pure)
Catalog number: B2010282
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Interferon-alpha2a (Highly Pure) expressed in E. coli. This protein acts as a regulatory mediator of the immune response with demonstrated antiviral and antitumor activities.
Storage: -20C
Keywords: rHuIFN-α2a; IFNA; IFNA2; IFN-a 2a
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Eigentler TK, Gutzmer R, Hauschild A, Heinzerling L, Schadendorf D, Nashan D,
Hölzle E, Kiecker F, Becker J, Sunderkötter C, Moll I, Richtig E, Pönitzsch I,
Pehamberger H, Kaufmann R, Pföhler C, Vogt T, Berking C, Praxmarer M, Garbe C;
Dermatologic Cooperative Oncology Group (DeCOG). Adjuvant treatment with
pegylated interferon α-2a versus low-dose interferon α-2a in patients with high-
risk melanoma: a randomized phase III DeCOG trial. Ann Oncol. 2016
Aug;27(8):1625-32.

2: Ma Y, Bao X, Xiong F, Wang J, Gu N, Guo J, Wu H, Lu J. The effect of
thymopentin add-on in hepatitis B e antigen positive chronic hepatitis B after
virus suppression by peginterferon plus entecavir therapy. Cell Mol Biol (Noisy-
le-grand). 2019 Feb 28;65(2):75-81.

3: Aruna, Li L. Anti-Interferon Alpha Antibodies in Patients with High-Risk
BCR/ABL-Negative Myeloproliferative Neoplasms Treated with Recombinant Human
Interferon-α. Med Sci Monit. 2018 Apr 17;24:2302-2309.

4: Dou Y, van Montfoort N, van den Bosch A, Janssen HLA, de Man RA, Buschow SI,
Woltman AM. Elevated serum levels of soluble CD14 in HBeAg-positive chronic HBV
patients upon Peginterferon treatment are associated with treatment response. J
Viral Hepat. 2019 Sep;26(9):1076-1085.

5: Covic A, Maftei ID, Mardare NG, Ioniţă-Radu F, Totolici C, Tuţă L, Golea O,
Covic M, Volovăţ C, Gusbeth-Tatomir P, Mircescu G. Analysis of safety and
efficacy of pegylated-interferon alpha-2a in hepatitis C virus positive
hemodialysis patients: results from a large, multicenter audit. J Nephrol. 2006
Nov-Dec;19(6):794-801.

6: Masci P, Bukowski RM, Patten PA, Osborn BL, Borden EC. New and modified
interferon alfas: preclinical and clinical data. Curr Oncol Rep. 2003
Mar;5(2):108-13.

7: Motzer RJ, Schwartz L, Law TM, Murphy BA, Hoffman AD, Albino AP, Vlamis V,
Nanus DM. Interferon alfa-2a and 13-cis-retinoic acid in renal cell carcinoma:
antitumor activity in a phase II trial and interactions in vitro. J Clin Oncol.
1995 Aug;13(8):1950-7.
8: Zhang YL, Zhang J, Cui LY. Interferon-α combined with lamivudine versus
lamivudine monotherapy for the emergence of YMDD mutations in chronic hepatitis
B infection: a meta-analysis of randomized controlled trials.
Hepatogastroenterology. 2015 Jan-Feb;62(137):133-9. PMID: 25911883.

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