Human Eotaxin-3/CCL26 (Recombinant)
Catalog Number: B2010355 (10 ug)
Human Eotaxin-3/CCL26 is a high quality research product used as highly pure Human Eotaxin-3/CCL26 expressed in E. coli. This protein acts as a protein that signals exclusively via the CCR3 receptor and has eosinophil-selective chemoattractant activity. Custom bulk orders of this product are available upon request.
Catalog number: B2010355
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Applications: highly pure Human Eotaxin-3/CCL26 expressed in E. coli. This protein acts as a protein that signals exclusively via the CCR3 receptor and has eosinophil-selective chemoattractant activity.
Keywords: rHuEotaxin-3/CCL26; C-C motif chemokine 26; MIP-4-alpha; TSC-1; SCYA26
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
1: Fujimoto T, Imaeda H, Takahashi K, Nishida A, Shioya M, Inatomi O, Bamba S,
Shiomi H, Tani M, Andoh A. Eotaxin-3 (CCL26) Expression in Human Pancreatic
Myofibroblasts. Pancreas. 2016 Mar;45(3):420-4.
2: Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and
eotaxin-3/CCL26 exert differential profibrogenic effects on human lung
fibroblasts. Ann Allergy Asthma Immunol. 2010 Jan;104(1):66-72.
3: Stubbs VE, Power C, Patel KD. Regulation of eotaxin-3/CCL26 expression in
human monocytic cells. Immunology. 2010 May;130(1):74-82.
4: Banwell ME, Tolley NS, Williams TJ, Mitchell TJ. Regulation of human
eotaxin-3/CCL26 expression: modulation by cytokines and glucocorticoids.
Cytokine. 2002 Mar 21;17(6):317-23.
5: Miyagawa Y, Murakami A, Ebihara N. The proteolytic effect of mast cell
tryptase to eotaxin-1/CCL11·eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by
conjunctival fibroblasts. Jpn J Ophthalmol. 2019 Mar;63(2):215-220.
6: Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B. Eotaxin-3/CCL26 is
a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with
a regulatory role. J Biol Chem. 2004 May 28;279(22):23357-63.
7: Rokudai A, Terui Y, Kuniyoshi R, Mishima Y, Mishima Y, Aizu-Yokota E, Sonoda
Y, Kasahara T, Hatake K. Differential regulation of eotaxin-1/CCL11 and
eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung
fibroblast. Biol Pharm Bull. 2006 Jun;29(6):1102-9.
8: Blanchard C, Durual S, Estienne M, Emami S, Vasseur S, Cuber JC.
Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated
by interleukin-4 and interleukin-13 via the signal transducer and activator of
transcription 6. Int J Biochem Cell Biol. 2005 Dec;37(12):2559-73.
9: Gela A, Kasetty G, Jovic S, Ekoff M, Nilsson G, Mörgelin M, Kjellström S,
Pease JE, Schmidtchen A, Egesten A. Eotaxin-3 (CCL26) exerts innate host defense
activities that are modulated by mast cell proteases. Allergy. 2015
10: Min JY, Ocampo CJ, Stevens WW, Price CPE, Thompson CF, Homma T, Huang JH,
Norton JE, Suh LA, Pothoven KL, Conley DB, Welch KC, Shintani-Smith S, Peters
AT, Grammer LC 3rd, Harris KE, Hulse KE, Kato A, Modyanov NN, Kern RC, Schleimer
RP, Tan BK. Proton pump inhibitors decrease eotaxin-3/CCL26 expression in
patients with chronic rhinosinusitis with nasal polyps: Possible role of the
nongastric H,K-ATPase. J Allergy Clin Immunol. 2017 Jan;139(1):130-141.e11.
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