Human DHPS Protein

Description

Human DHPS Protein
Catalog number: B2012147
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: MIG13 protein, DS protein, Migration inducing gene 13., Deoxyhypusine synthase DHS protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hammoudeh DI, Zhao Y, White SW, Lee RE. Replacing sulfa drugs with novel DHPS inhibitors Future Med Chem. 2013 Jul;5(11):1331-40.
2: Becker AE, Wu PK, Park JI. eIF5A-Independent Role of DHPS in p21(CIP1) and Cell Fate Regulation Int J Mol Sci. 2021 Dec 7;22(24):13187.
3: Kar RK, Hanner AS, Starost MF, Springer D, Mastracci TL, Mirmira RG, Park MH. Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice J Biol Chem. 2021 Nov;297(5):101333.
4: Velena A, Zarkovic N, Gall Troselj K, Bisenieks E, Krauze A, Poikans J, Duburs G. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress Oxid Med Cell Longev. 2016;2016:1892412.
5: Lindner B, Martin E, Steininger M, Bundalo A, Lenter M, Zuber J, Schuler M. A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells Sci Rep. 2021 Jun 21;11(1):12973.
6: Kaur H, Narasimhan B. Antimicrobial Activity of Diazenyl Derivatives: An Update Curr Top Med Chem. 2018;18(1):3-21.
7: Tanaka Y, Kurasawa O, Yokota A, Klein MG, Ono K, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Morishita D, Kitazawa S, Uchiyama N, Ogawa K, Kimura H, Imamura S. Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase J Med Chem. 2020 Mar 26;63(6):3215-3226.
8: Coni S, Serrao SM, Yurtsever ZN, Di Magno L, Bordone R, Bertani C, Licursi V, Ianniello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G. Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation Cell Death Dis. 2020 Dec 10;11(12):1045.
9: Wang C, Chen Z, Nie L, Tang M, Feng X, Su D, Zhang H, Xiong Y, Park JM, Chen J. Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation Oncogenesis. 2020 Sep 28;9(9):85.
10: Natale NR, Steiger SA. 4-isoxazolyl-1,4-dihydropyridines: a tale of two scaffolds Future Med Chem. 2014 May;6(8):923-43.

Products Related to Human DHPS Protein can be found at Proteins