Human DENR Protein

Description

Human DENR Protein
Catalog number: B2012148
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: SMAP-3 protein, DRP protein, Density-regulated protein, DRP1 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA. Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1 Cell Rep. 2017 Jul 18;20(3):521-528.
2: Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion Nat Commun. 2022 Apr 19;13(1):2059.
3: Mazan-Mamczarz K, Gartenhaus RB. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1 Cancer Genomics Proteomics. 2007 May-Jun;4(3):233-9.
4: Lomakin IB, De S, Wang J, Borkar AN, Steitz TA. Crystal structure of the C-terminal domain of DENR Comput Struct Biotechnol J. 2020 Mar 19;18:696-704.
5: Lomakin IB, Dmitriev SE, Steitz TA. Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):528-533.
6: Clemm von Hohenberg K, Müller S, Schleich S, Meister M, Bohlen J, Hofmann TG, Teleman AA. Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division Nat Commun. 2022 Feb 3;13(1):668.
7: Ahmed YL, Schleich S, Bohlen J, Mandel N, Simon B, Sinning I, Teleman AA. DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation PLoS Biol. 2018 Jun 11;16(6):e2005160.
8: Schleich S, Acevedo JM, Clemm von Hohenberg K, Teleman AA. Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells Sci Rep. 2017 Jun 16;7(1):3722.
9: Castelo-Szekely V, De Matos M, Tusup M, Pascolo S, Ule J, Gatfield D. Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock Nucleic Acids Res. 2019 Jun 4;47(10):5193-5209.
10: Bohlen J, Harbrecht L, Blanco S, Clemm von Hohenberg K, Fenzl K, Kramer G, Bukau B, Teleman AA. DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 Nat Commun. 2020 Sep 16;11(1):4676.

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