Human CXCL13 Protein

Description

Human CXCL13 Protein
Catalog number: B2012085
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 250 µg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Chemokine (C-X-C motif) ligand 13 protein, ANGIE protein, ANGIE2 protein, BCA-1 protein, BCA1 protein, BLC protein, BLR1L protein, SCYB13 protein, CXCL 13 protein, CXCL-13 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hussain M, Adah D, Tariq M, Lu Y, Zhang J, Liu J. CXCL13/CXCR5 signaling axis in cancer Life Sci. 2019 Jun 15;227:175-186.
2: Bellamri N, Viel R, Morzadec C, Lecureur V, Joannes A, de Latour B, Llamas-Gutierrez F, Wollin L, Jouneau S, Vernhet L. TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages J Immunol. 2020 May 1;204(9):2492-2502.
3: Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pagès F, Speicher MR, Trajanoski Z, Galon J. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer Immunity. 2013 Oct 17;39(4):782-95.
4: Jiang BC, Cao DL, Zhang X, Zhang ZJ, He LN, Li CH, Zhang WW, Wu XB, Berta T, Ji RR, Gao YJ. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5 J Clin Invest. 2016 Feb;126(2):745-61.
5: Koedel U, Fingerle V, Pfister HW. Lyme neuroborreliosis-epidemiology, diagnosis and management Nat Rev Neurol. 2015 Aug;11(8):446-56.
6: Li JP, Wu CY, Chen MY, Liu SX, Yan SM, Kang YF, Sun C, Grandis JR, Zeng MS, Zhong Q. PD-1(+)CXCR5(-)CD4(+) Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma J Immunother Cancer. 2021 Jul;9(7):e002101.
7: Liu JF, Lee CW, Lin CY, Chao CC, Chang TM, Han CK, Huang YL, Fong YC, Tang CH. CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma Int J Mol Sci. 2020 Aug 24;21(17):6095.
8: Dai S, Zeng H, Liu Z, Jin K, Jiang W, Wang Z, Lin Z, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Liu L, Zhu Y, Xu L, Qu Y, Guo J, Xu J. Intratumoral CXCL13(+)CD8(+)T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma J Immunother Cancer. 2021 Feb;9(2):e001823.
9: Yang M, Lu J, Zhang G, Wang Y, He M, Xu Q, Xu C, Liu H. CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer J Immunother Cancer. 2021 Jan;9(1):e001136.
10: Aoki T, Chong LC, Takata K, Milne K, Marshall A, Chavez EA, Miyata-Takata T, Ben-Neriah S, Unrau D, Telenius A, Boyle M, Weng AP, Savage KJ, Scott DW, Farinha P, Shah SP, Nelson BH, Steidl C. Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2105822118.

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