Human CRK Protein

Description

Human CRK Protein
Catalog number: B2012029
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Proto-oncogene c-Crk protein, Adapter molecule crk protein, CRKII, p38 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu D. The adaptor protein Crk in immune response Immunol Cell Biol. 2014 Jan;92(1):80-9.
2: Uemura S, Wang L, Tsuda M, Suzuka J, Tanikawa S, Sugino H, Nakamura T, Mitsuhashi T, Hirano S, Tanaka S. Signaling adaptor protein Crk is involved in malignant feature of pancreatic cancer associated with phosphorylation of c-Met Biochem Biophys Res Commun. 2020 Apr 2;524(2):378-384.
3: Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M, Tanaka S. Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer Oncotarget. 2016 May 10;7(19):27094-107.
4: Linghu H, Tsuda M, Makino Y, Sakai M, Watanabe T, Ichihara S, Sawa H, Nagashima K, Mochizuki N, Tanaka S. Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS Oncogene. 2006 Jun 15;25(25):3547-56.
5: Feng R, Sah BK, Beeharry MK, Yuan F, Su L, Jin X, Yan M, Liu B, Li C, Zhu Z. Dysregulation of miR-126/Crk protein axis predicts poor prognosis in gastric cancer patients Cancer Biomark. 2018 Feb 6;21(2):335-343.
6: Matsumoto R, Tsuda M, Wang L, Maishi N, Abe T, Kimura T, Tanino M, Nishihara H, Hida K, Ohba Y, Shinohara N, Nonomura K, Tanaka S. Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop Cancer Sci. 2015 Jun;106(6):709-17.
7: Park T. Crk and CrkL as Therapeutic Targets for Cancer Treatment Cells. 2021 Mar 27;10(4):739.
8: Feller SM, Lewitzky M. Potential disease targets for drugs that disrupt protein– protein interactions of Grb2 and Crk family adaptors Curr Pharm Des. 2006;12(5):529-48.
9: Watanabe T, Tsuda M, Tanaka S, Ohba Y, Kawaguchi H, Majima T, Sawa H, Minami A. Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation Mol Cancer Res. 2009 Sep;7(9):1582-92.
10: Nishihara H, Tanaka S, Tsuda M, Oikawa S, Maeda M, Shimizu M, Shinomiya H, Tanigami A, Sawa H, Nagashima K. Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers Cancer Lett. 2002 Jun 6;180(1):55-61.

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