Human COPS8 Protein

Product Description

Human COPS8 Protein
Catalog number: B2012008
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: COPS8, SGN8 protein, COPS-8 protein, CSN8 protein, COP9 protein, COPS-8, COP9 signalosome complex subunit 8 protein, COPS 8, COPS 8 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ju S, Wang F, Wang Y, Ju S. CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal transition and dormancy of colorectal cancer cells Mol Cancer. 2020 Dec 1;19(1):168.
2: Li P, Gao L, Cui T, Zhang W, Zhao Z, Chen L. Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2519-2525.
3: Crone SG, Jacobsen A, Federspiel B, Bardram L, Krogh A, Lund AH, Friis-Hansen L. microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer Mol Cancer. 2012 Sep 20;11:71.
4: Niikura Y, Kitagawa R, Ogi H, Kitagawa K. SGT1-HSP90 complex is required for CENP-A deposition at centromeres Cell Cycle. 2017 Sep 17;16(18):1683-1694.
5: Niikura Y, Kitagawa R, Fang L, Kitagawa K. CENP-A Ubiquitylation Is Indispensable to Cell Viability Dev Cell. 2019 Sep 23;50(6):683-689.e6.
6: Sun L. COPS8 in cutaneous melanoma: an oncogene that accelerates the malignant development of tumor cells and predicts poor prognosis Biosci Biotechnol Biochem. 2021 Feb 18;85(2):242-250.
7: Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere Molecules. 2019 Jan 22;24(3):402.
8: Mahmoodi M, Nguyen-Dumont T, Hammet F, Pope BJ, Park DJ, Southey MC, Darlow JM, Bruinsma F, Winship I. Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study Fam Cancer. 2017 Jul;16(3):411-416.
9: Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions Cell Rep. 2016 Apr 5;15(1):61-76.
10: Niikura Y, Kitagawa R, Ogi H, Abdulle R, Pagala V, Kitagawa K. CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere Dev Cell. 2015 Mar 9;32(5):589-603.

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