Human CHMP6 Protein

Description

Human CHMP6 Protein
Catalog number: B2011945
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CHMP-6 protein, CHMP-6, CHMP 6 protein, VPS20 protein, CHMP6, Charged multivesicular body protein 6 protein, CHMP 6
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T, Uchiyama Y, Maki M. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting Biochem J. 2005 Apr 1;387(Pt 1):17-26.
2: Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation J Biol Chem. 2019 Dec 13;294(50):18952-18966.
3: Dai E, Meng L, Kang R, Wang X, Tang D. ESCRT-III-dependent membrane repair blocks ferroptosis Biochem Biophys Res Commun. 2020 Feb 5;522(2):415-421.
4: Yan M, Zheng T. Role of the endolysosomal pathway and exosome release in tau propagation Neurochem Int. 2021 May;145:104988.
5: Zheng ZY, Xu L, Bar-Sagi D, Chang EC. Escorting Ras Small GTPases. 2012 Oct-Dec;3(4):236-9.
6: Kuang Z, Seo EJ, Leis J. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15 J Virol. 2011 Jul;85(14):7153-61.
7: Davis LJ, Bright NA, Edgar JR, Parkinson MDJ, Wartosch L, Mantell J, Peden AA, Luzio JP. Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway J Cell Sci. 2021 May 15;134(10):jcs255463.
8: Fu D, Tian L, Peng Z, Deng W, Yuan J, Ma D, Shi T, Li D, Wang Y. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells Biosci Biotechnol Biochem. 2009 Mar 23;73(3):494-501.
9: Goliand I, Nachmias D, Gershony O, Elia N. Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death Mol Biol Cell. 2014 Nov 15;25(23):3740-8.
10: Parkinson MD, Piper SC, Bright NA, Evans JL, Boname JM, Bowers K, Lehner PJ, Luzio JP. A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I Biochem J. 2015 Oct 1;471(1):79-88.

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