Human CHI3L2 Protein

Description

Human CHI3L2 Protein
Catalog number: B2011939
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 500 µg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CHI3L2 protein, CHIL2 protein, YKL-39 protein, YKL39 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ogunkolade BW, Adaikalakoteswari A, Cardoso SR, Lowe R, Patel N, Rakyan V, Finer S, Wabitsch M, Saravanan P, Tripathi G, Bochukova E, Hitman GA. An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes Epigenetics. 2021 Nov 25:1-15.
2: Thompson AG, Gray E, Bampton A, Raciborska D, Talbot K, Turner MR. CSF chitinase proteins in amyotrophic lateral sclerosis J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1215-1220.
3: Areshkov PA, Kavsan VM. Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells Tsitol Genet. 2010 Jan-Feb;44(1):3-9.
4: Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D’Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M. Clonally expanded EOMES(+) Tr1-like cells in primary and metastatic tumors are associated with disease progression Nat Immunol. 2021 Jun;22(6):735-745.
5: Avdieiev S, Savinska L, Filonenko V, Kavsan V. Chitinase 3-like 2 protein monoclonal antibodies Hybridoma (Larchmt). 2012 Feb;31(1):32-9.
6: Areshkov PO, Avdieiev SS, Balynska OV, Leroith D, Kavsan VM. Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation Int J Biol Sci. 2012;8(1):39-48.
7: Comabella M, Sastre-Garriga J, Borras E, Villar LM, Saiz A, Martínez-Yélamos S, García-Merino JA, Pinteac R, Fissolo N, Sánchez López AJ, Costa-Frossard L, Blanco Y, Llufriu S, Vidal-Jordana A, Sabidó E, Montalban X. CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis Neurol Neuroimmunol Neuroinflamm. 2021 Sep 8;8(6):e1082.
8: Ranok A, Wongsantichon J, Robinson RC, Suginta W. Structural and thermodynamic insights into chitooligosaccharide binding to human cartilage chitinase 3-like protein 2 (CHI3L2 or YKL-39) J Biol Chem. 2015 Jan 30;290(5):2617-29.
9: Thompson AG, Gray E, Thézénas ML, Charles PD, Evetts S, Hu MT, Talbot K, Fischer R, Kessler BM, Turner MR. Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis Ann Neurol. 2018 Feb;83(2):258-268.
10: Moreno-Rodriguez M, Perez SE, Nadeem M, Malek-Ahmadi M, Mufson EJ. Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease J Neuroinflammation. 2020 Feb 17;17(1):58.

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