Human BIP Protein

Description

Human BIP Protein
Catalog number: B2011608
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: glucose-regulated protein 78kD protein, HSPA5 protein, heat shock 70kDa protein 5 protein, Binding immunoglobulin protein , MIF2, GRP78 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ibrahim IM, Abdelmalek DH, Elfiky AA. GRP78: A cell’s response to stress Life Sci. 2019 Jun 1;226:156-163.
2: Wang J, Lee J, Liem D, Ping P. HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum Gene. 2017 Jun 30;618:14-23.
3: Kopp MC, Larburu N, Durairaj V, Adams CJ, Ali MMU. UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor Nat Struct Mol Biol. 2019 Nov;26(11):1053-1062.
4: Bandla S, Diaz S, Nasheuer HP, FitzGerald U. ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn(2) FEBS Open Bio. 2019 Aug;9(8):1355-1369.
5: Pobre KFR, Poet GJ, Hendershot LM. The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends J Biol Chem. 2019 Feb 8;294(6):2098-2108.
6: Kabakov AE, Gabai VL. HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for Therapy Cells. 2021 Dec 7;10(12):3446.
7: Kania E, Pająk B, Orzechowski A. Calcium homeostasis and ER stress in control of autophagy in cancer cells Biomed Res Int. 2015;2015:352794.
8: Meyer BA, Doroudgar S. ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart Cells. 2020 Sep 10;9(9):2066.
9: Kabakov A, Yakimova A, Matchuk O. Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy Cells. 2020 Apr 6;9(4):892.
10: Yang L, Guan G, Lei L, Lv Q, Liu S, Zhan X, Jiang Z, Gu X. Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy Cell Stress Chaperones. 2018 Nov;23(6):1283-1294.

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