Human BCA-1/CXCL13 (Recombinant)


Catalog Number: B2010341 (10 ug)
Human BCA-1/CXCL13 is a high quality research product used as highly pure Human BCA-1/CXCL13 expressed in E. coli. This protein acts as an efficient and selective attractant for B lymphocytes that also acts as a B cell homing chemokine. Custom bulk orders of this product are available upon request.

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SKU: B2010341 Categories: , ,


Human BCA-1/CXCL13
Catalog number: B2010341
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human BCA-1/CXCL13 expressed in E. coli. This protein acts as an efficient and selective attractant for B lymphocytes that also acts as a B cell homing chemokine.
Storage: -20C
Keywords: rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Steinmetz OM, Panzer U, Kneissler U, Harendza S, Lipp M, Helmchen U, Stahl
RA. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster
formation in acute renal transplant rejection. Kidney Int. 2005

2: Ezzat M, El-Gammasy T, Shaheen K, Shokr E. Elevated production of serum
B-cell-attracting chemokine-1 (BCA-1/CXCL13) is correlated with childhood-onset
lupus disease activity, severity, and renal involvement. Lupus. 2011

3: Hafez SS, Saad Wel S, Shedid NH. B-cell-attracting chemokine-1 (BCA-1/CXCL13)
in systemic lupus erythematosus, its correlation to disease activity and renal
involvement. Egypt J Immunol. 2014;21(2):23-32.

4: Pranzatelli MR, Tate ED, Travelstead AL, Verhulst SJ. Chemokine/cytokine
profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in
childhood OMS. Cytokine. 2011 Mar;53(3):384-9.

5: Shiels MS, Pfeiffer RM, Hildesheim A, Engels EA, Kemp TJ, Park JH, Katki HA,
Koshiol J, Shelton G, Caporaso NE, Pinto LA, Chaturvedi AK. Circulating
inflammation markers and prospective risk for lung cancer. J Natl Cancer Inst.
2013 Dec 18;105(24):1871-80.

6: Steinmetz OM, Stahl RA, Panzer U. Chemokines and B cells in renal
inflammation and allograft rejection. Front Biosci (Schol Ed). 2009 Jun

7: Steinmetz OM, Lange-Hüsken F, Turner JE, Vernauer A, Helmchen U, Stahl RA,
Thaiss F, Panzer U. Rituximab removes intrarenal B cell clusters in patients
with renal vascular allograft rejection. Transplantation. 2007 Oct
15;84(7):842-50. doi: 10.1097/ PMID: 17984836.

8: Lechner CJ, Gantin RG, Seeger T, Sarnecka A, Portillo J, Schulz-Key H,
Karabou PK, Helling-Giese G, Heuschkel C, Banla M, Soboslay PT. Chemokines and
cytokines in patients with an occult Onchocerca volvulus infection. Microbes
Infect. 2012 May;14(5):438-46.

9: Barbieri F, Bajetto A, Porcile C, Pattarozzi A, Massa A, Lunardi G, Zona G,
Dorcaratto A, Ravetti JL, Spaziante R, Schettini G, Florio T. CXC receptor and
chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2
and stimulates meningioma cell proliferation. Ann N Y Acad Sci. 2006

10: Meijer J, Zeelenberg IS, Sipos B, Roos E. The CXCR5 chemokine receptor is
expressed by carcinoma cells and promotes growth of colon carcinoma in the
liver. Cancer Res. 2006 Oct 1;66(19):9576-82.

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