Human ASS1 Protein

Product Description

Human ASS1 Protein
Catalog number: B2011800
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: ASS1, ASS 1, ASS 1 protein, ASS-1 protein, ASS-1, ASS protein, CTLN1 protein, Argininosuccinate synthase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zou Z, Hu X, Luo T, Ming Z, Chen X, Xia L, Luo W, Li J, Xu N, Chen L, Cao D, Wen M, Kong F, Peng K, Xie Y, Li X, Ma D, Yang C, Chen C, Yi W, Liu O, Liu S, Luo J, Luo Z. Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor Nat Commun. 2021 Apr 15;12(1):2263.
2: Du D, Liu C, Qin M, Zhang X, Xi T, Yuan S, Hao H, Xiong J. Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma Acta Pharm Sin B. 2022 Feb;12(2):558-580.
3: Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Ulitsky I, Nagamani SC, Ruppin E, Erez A. Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis Nature. 2015 Nov 19;527(7578):379-383.
4: Engel K, Höhne W, Häberle J. Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene Hum Mutat. 2009 Mar;30(3):300-7.
5: Mao Y, Shi D, Li G, Jiang P. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses Mol Cell. 2022 Feb 3;82(3):527-541.e7.
6: Li JM, Yang DC, Oldham J, Linderholm A, Zhang J, Liu J, Kenyon NJ, Chen CH. Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis Mol Ther. 2021 Apr 7;29(4):1487-1500.
7: Diez-Fernandez C, Rüfenacht V, Häberle J. Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations Hum Mutat. 2017 May;38(5):471-484.
8: Monge-García V, Llorca-Tolón L, Gasparini-Berenguer R, Monge-Argilés JA. [Role of the Aß1-42/Aß1-40 ratio in the concept ‘Alzheimer’s disease contributes to mild cognitive impairment’] Rev Neurol. 2021 Jun 1;72(11):371-376.
9: Xie B, Chen R, Wang J, Luo J, Li W, Chen S. [ASS1 gene mutation in a neonate with citrullinemia type I] Zhonghua Er Ke Za Zhi. 2014 Oct;52(10):788-91.
10: Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, Crook T, Szlosarek PW. Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer Int J Cancer. 2010 Jun 15;126(12):2762-72.

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