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Human Aprataxin Protein

$895.00

Catalog Number: B2011753 (50 µg)
Human Aprataxin Protein is a high quality recombinant human Aprataxin protein His tagged and expressed in E.coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011753 Categories: ,

Description

Human Aprataxin Protein
Catalog number: B2011753
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 0.25 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: EOAHA protein, FHA HIT protein, Aprataxin homolog protein, AOA1 protein, EAOH protein, AOA protein, Forkhead associated domain histidine triad like protein, Ataxia1 early onset with hypoalbuminemia protein, Forkhead associated domain histidine triad like
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Iyama T, Wilson DM 3rd. DNA repair mechanisms in dividing and non-dividing cells DNA Repair (Amst). 2013 Aug;12(8):620-36.
2: Gueven N, Becherel OJ, Kijas AW, Chen P, Howe O, Rudolph JH, Gatti R, Date H, Onodera O, Taucher-Scholz G, Lavin MF. Aprataxin, a novel protein that protects against genotoxic stress Hum Mol Genet. 2004 May 15;13(10):1081-93.
3: Sykora P, Croteau DL, Bohr VA, Wilson DM 3rd. Aprataxin localizes to mitochondria and preserves mitochondrial function Proc Natl Acad Sci U S A. 2011 May 3;108(18):7437-42.
4: Asai H, Hirano M, Shimada K, Kiriyama T, Furiya Y, Ikeda M, Iwamoto T, Mori T, Nishinaka K, Konishi N, Udaka F, Ueno S. Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin Hum Mol Genet. 2009 Oct 1;18(19):3533-43.
5: Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S. Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein Ann Neurol. 2004 Feb;55(2):241-9.
6: Becherel OJ, Gueven N, Birrell GW, Schreiber V, Suraweera A, Jakob B, Taucher-Scholz G, Lavin MF. Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription Hum Mol Genet. 2006 Jul 15;15(14):2239-49.
7: Palau F, Espinós C. Autosomal recessive cerebellar ataxias Orphanet J Rare Dis. 2006 Nov 17;1:47.
8: Schellenberg MJ, Tumbale PP, Williams RS. Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease Prog Biophys Mol Biol. 2015 Mar;117(2-3):157-165.
9: Seidle HF, Bieganowski P, Brenner C. Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin J Biol Chem. 2005 Jun 3;280(22):20927-31.
10: Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily FEBS J. 2013 Jul;280(14):3389-98.

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