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Human APP Protein

$795.00

Catalog Number: B2011752 (100 µg)
Human APP Protein is a high quality recombinant human APP protein His tagged and expressed in E.coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011752 Categories: ,

Description

Human APP Protein
Catalog number: B2011752
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AD1 protein, ABETA protein, CVAP protein, CTF gamma protein, ABPP protein, PN2 protein, APPI protein, AAA protein, Amyloid beta A4 protein protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu T, Zhang T, Nicolas M, Boussicault L, Rice H, Soldano A, Claeys A, Petrova I, Fradkin L, De Strooper B, Potier MC, Hassan BA. The amyloid precursor protein is a conserved Wnt receptor Elife. 2021 Sep 9;10:e69199.
2: Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber MJ, Alani S, Bocchetta M. Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells J Cell Physiol. 2015 May;230(5):1064-74.
3: Matsuda S, Senda T. BRI2 as an anti-Alzheimer gene Med Mol Morphol. 2019 Mar;52(1):1-7.
4: Hao Y, Perkinton MS, Chan WW, Chan HY, Miller CC, Lau KF. GULP1 is a novel APP-interacting protein that alters APP processing Biochem J. 2011 Jun 15;436(3):631-9.
5: Naves FJ, Calzada B, Cabal A, Alonso-Cortina V, del Valle ME, Fernandez-Sanchez MT, Vega JA. Expression of beta-amyloid precursor protein (APP) in human dorsal root ganglia Neurosci Lett. 1994 Nov 7;181(1-2):73-7.
6: Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D. Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway Cell Death Dis. 2014 Aug 28;5(8):e1391.
7: Augustin V, Kins S. Fe65: A Scaffolding Protein of Actin Regulators Cells. 2021 Jun 25;10(7):1599.
8: Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes J Biol Chem. 2018 Jul 20;293(29):11341-11357.
9: Wirak DO, Bayney R, Kundel CA, Lee A, Scangos GA, Trapp BD, Unterbeck AJ. Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice EMBO J. 1991 Feb;10(2):289-96.
10: Sun M, Asghar SZ, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb Neurobiol Dis. 2016 Sep;93:1-11.

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