Sale!

Human Alanyl-tRNA Synthetase (AARS)

$495.00

Catalog Number: B2012370 (20 ug)
Human Alanyl-tRNA Synthetase (AARS) is a high quality Alanyl-tRNA synthetase produced in Sf9 cells. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

In stock

SKU: B2012370 Categories: , Tag:

Description

Human Alanyl-tRNA Synthetase (AARS)
Catalog number: B2012370
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 ug
Molecular Weight or Concentration: 107.6 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Alanyl-tRNA synthetase cytoplasmic, Alanine-tRNA ligase, AlaRS
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zeng QY, Peng GX, Li G, Zhou JB, Zheng WQ, Xue MQ, Wang ED, Zhou XL. The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase Nucleic Acids Res. 2019 Apr 8;47(6):3072-3085.
2: Mahler M, Miller FW, Fritzler MJ. Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review Autoimmun Rev. 2014 Apr-May;13(4-5):367-71.
3: Zhang H, Wu J, Lyu Z, Ling J. Impact of alanyl-tRNA synthetase editing deficiency in yeast Nucleic Acids Res. 2021 Sep 27;49(17):9953-9964.
4: Zhao X, Han J, Zhu L, Xiao Y, Wang C, Hong F, Jiang P, Guan MX. Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids Int J Biol Sci. 2018 Aug 6;14(11):1437-1444.
5: Zhan X, Yan W, Wang Y, Li Q, Shi X, Gao Y, Ye Q. Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China BMC Pulm Med. 2021 Feb 12;21(1):57.
6: Shiba K, Ripmaster T, Suzuki N, Nichols R, Plotz P, Noda T, Schimmel P. Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition Biochemistry. 1995 Aug 22;34(33):10340-9.
7: Vargas-Rodriguez O, Bakhtina M, McGowan D, Abid J, Goto Y, Suga H, Musier-Forsyth K. Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity J Biol Chem. 2020 Nov 27;295(48):16180-16190.
8: Kuo ME, Antonellis A, Shakkottai VG. Alanyl-tRNA Synthetase 2 (AARS2)-Related Ataxia Without Leukoencephalopathy Cerebellum. 2020 Feb;19(1):154-160.
9: Kelly P, Hadi-Nezhad F, Liu DY, Lawrence TJ, Linington RG, Ibba M, Ardell DH. Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens PLoS Negl Trop Dis. 2020 Feb 27;14(2):e0007983.
10: Fine AS, Nemeth CL, Kaufman ML, Fatemi A. Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination J Neurodev Disord. 2019 Dec 16;11(1):29.

Products Related to Human Alanyl-tRNA Synthetase (AARS) can be found at Enzymes

How to Order

1- Order online using our website’s automated shopping cart and checkout system (available 24/7).

2- Order by email: info@moleculardepot.com (we accept electronic PO, available 24/7).

3- Order by Fax: 1-858-437-9884 (available 24/7).

4- Order by phone: 1-858-900-3210 (6 am – 8 pm PST).

5- Order by Text/SMS: 1-858-900-3210 (6 am – 8 pm PST).