HCV NS3/4A Protease Substrate


Catalog Number: B2011251 (1 mg)
HCV NS3/4A Protease Substrate is a high quality highly sensitive FRET substrate for assaying HCV NS3/4A protease activity. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011251 Categories: ,


HCV NS3/4A Protease Substrate
Catalog number: B2011251
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1913.8 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: HCV NS3-4A Protease Substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Lin C. HCV NS3-4A Serine Protease In: Tan SL, editor. Hepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 6.
2: Matthew AN, Zephyr J, Nageswara Rao D, Henes M, Kamran W, Kosovrasti K, Hedger AK, Lockbaum GJ, Timm J, Ali A, Kurt Yilmaz N, Schiffer CA. Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors mBio. 2020 Mar 31;11(2):e00172-20.
3: Tran HTL, Morikawa K, Anggakusuma, Zibi R, Thi VLD, Penin F, Heim MH, Quadroni M, Pietschmann T, Gouttenoire J, Moradpour D. OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease PLoS One. 2020 Jul 22;15(7):e0236447.
4: Özen A, Prachanronarong K, Matthew AN, Soumana DI, Schiffer CA. Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors Crit Rev Biochem Mol Biol. 2019 Feb;54(1):11-26.
5: Dultz G, Shimakami T, Schneider M, Murai K, Yamane D, Marion A, Zeitler TM, Stross C, Grimm C, Richter RM, Bäumer K, Yi M, Biondi RM, Zeuzem S, Tampé R, Antes I, Lange CM, Welsch C. Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors J Biol Chem. 2020 Oct 2;295(40):13862-13874.
6: Ozdemir Isik G, Ozer AN. Prediction of substrate specificity in NS3/4A serine protease by biased sequence search threading J Biomol Struct Dyn. 2017 Apr;35(5):1102-1114.
7: McCauley JA, Rudd MT. Hepatitis C virus NS3/4a protease inhibitors Curr Opin Pharmacol. 2016 Oct;30:84-92.
8: Pillaiyar T, Namasivayam V, Manickam M. Macrocyclic Hepatitis C Virus NS3/4A Protease Inhibitors: An Overview of Medicinal Chemistry Curr Med Chem. 2016;23(29):3404-3447.
9: Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB. DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication Virology. 2013 Jan 20;435(2):385-94.
10: Zhu H, Briggs JM. Mechanistic role of NS4A and substrate in the activation of HCV NS3 protease Proteins. 2011 Aug;79(8):2428-43.

Products Related to HCV NS3/4A Protease Substrate can be found at Substrates

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