GHBP Human (Highly Pure, Lyophilized)

Description

GHBP Human (Highly Pure)
Catalog number: B2010435
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 ug
Molecular Weight or Concentration: 28.1 kDa
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: Highly pure human GHBP. This protein acts as a transmembrane receptor for growth hormone.
Storage: -20C
Keywords: Somatotropin receptor, GH receptor, GHR, GHBP
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hansen TK, Fisker S, Hansen B, Sørensen HH, Christiansen JS, Jørgensen JO,
ØRskov H. Impact of GHBP interference on estimates of GH and GH
pharmacokinetics. Clin Endocrinol (Oxf). 2002 Dec;57(6):779-86.

2: Mullis PE, Eblé A, Wagner JK, Holl RW, Silbergeld A, Laron Z. Effect of
different serum concentrations of growth hormone-binding protein (GHBP) on the
regulation of GH receptor/GHBP gene transcription in a human hepatoma cell line.
Horm Res. 1997;47(2):73-80.

3: De Vries WR, Koppeschaar HP, Bol E, Roelen CA, Donker GH, Doerga ME, Osman-
Dualeh M, Snel YE. Intersubject responsiveness of high-affinity growth hormone
(GH)-binding protein (GH_BP) to long-term GH replacement therapy. J Endocrinol
Invest. 2000 Jul-Aug;23(7):449-56.

4: Davis SL, Wehr NB, Laird DM, Hammond AC. Serum growth hormone-binding protein
(GHBP) in domestic animals as measured by ELISA. J Anim Sci. 1994
Jul;72(7):1719-27.

5: Schilbach K, Bidlingmaier M. Growth hormone binding protein – physiological
and analytical aspects. Best Pract Res Clin Endocrinol Metab. 2015
Oct;29(5):671-83.

6: Fusco A, Miele L, D’Uonnolo A, Forgione A, Riccardi L, Cefalo C, Barini A,
Bianchi A, Giampietro A, Cimino V, Landolfi R, Grieco A, De Marinis L.
Nonalcoholic fatty liver disease is associated with increased GH_BP and reduced
GH/IGF-I levels. Clin Endocrinol (Oxf). 2012 Oct;77(4):531-6.

7: Zhang Y, Jiang J, Black RA, Baumann G, Frank SJ. Tumor necrosis factor-alpha
converting enzyme (TACE) is a growth hormone binding protein (GH_BP) sheddase:
the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor
proteolysis and GHBP generation. Endocrinology. 2000 Dec;141(12):4342-8.
8: Kratzsch J, Dehmel B, Pulzer F, Keller E, Englaro P, Blum WF, Wabitsch M.
Increased serum GHBP levels in obese pubertal children and adolescents:
relationship to body composition, leptin and indicators of metabolic
disturbances. Int J Obes Relat Metab Disord. 1997 Dec;21(12):1130-6.

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