Furin (Human Recombinant)

Description

Furin (Human Recombinant)
Catalog number: B2010567
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 uL
Molecular Weight or Concentration: na
Supplied as: Solution
Applications: molecular in the study of various cellular systems
Storage: −70°C
Keywords: Furin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The
spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like
cleavage site absent in CoV of the same clade. Antiviral Res. 2020
Apr;176:104742.

2: Hasan A, Paray BA, Hussain A, Qadir FA, Attar F, Aziz FM, Sharifi M,
Derakhshankhah H, Rasti B, Mehrabi M, Shahpasand K, Saboury AA, Falahati M. A
review on the cleavage priming of the spike protein on coronavirus by
angiotensin-converting enzyme-2 and furin. J Biomol Struct Dyn. 2021
May;39(8):3025-3033.

3: Örd M, Faustova I, Loog M. The sequence at Spike S1/S2 site enables cleavage
by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV.
Sci Rep. 2020 Oct 9;10(1):16944.

4: Cao R, Zhang Y, Du J, Chen S, Wang N, Ying H, Shen B. Increased FURIN
expression in rheumatoid arthritis patients and its anti-inflammatory effect. J
Clin Lab Anal. 2020 Dec;34(12):e23530.

5: Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland
T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick
LJ, Duprex WP. SARS-CoV-2 growth, furin_cleavage-site adaptation and
neutralization using serum from acutely infected hospitalized COVID-19 patients.
J Gen Virol. 2020 Nov;101(11):1156-1169.

6: Jaaks P, Bernasconi M. The proprotein convertase furin_ in tumour progression.
Int J Cancer. 2017 Aug 15;141(4):654-663.

7: Couture F, Kwiatkowska A, Dory YL, Day R. Therapeutic uses of furin_ and its
inhibitors: a patent review. Expert Opin Ther Pat. 2015 Apr;25(4):379-96.

8: Solovyeva NI, Gureeva TA, Timoshenko OS, Moskvitina TA, Kugaevskaya EV. Furin
kak proproteinkonvertaza i ego rol’ v normal’nykh i patologicheskikh
biologicheskikh protsessakh [Furin as proprotein convertase and its role in
normaland pathological biological processes]. Biomed Khim. 2016
Nov;62(6):609-621. Russian.

9: Tang T, Jaimes JA, Bidon MK, Straus MR, Daniel S, Whittaker GR. Proteolytic
Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of
Proteases beyond Furin. ACS Infect Dis. 2021 Feb 12;7(2):264-272.
10: Baumann J, Huang SF, Gassmann M, Tsao CC, Ogunshola OO. Furin inhibition
prevents hypoxic and TGFβ-mediated blood-brain barrier disruption. Exp Cell Res.
2019 Oct 15;383(2):111503.

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